2023年7月18日 · Each thymocyte can audition for positive selection with several different TCRs, owing to the unique architecture of the TCRα gene locus, which contains multiple variable (V) and joining (J) gene...

After describing population dynamic models, models to infer cell-cycle speed in the thymus in vivo, and estimation of cell death through the selection steps, we highlight pioneering models that link thymocyte motility and signaling to cell fate and population dynamics. We discuss how next-generation models may be formulated in the context of ...

Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo. J Immunol. 2013;191(3):1200–1209. [ DOI ] [ PubMed ] [ Google Scholar ]

Thymocyte differentiation is a highly regulated process dependent not only on interactions between early T cell precursors with stromal cells but also on the presence of soluble molecules such as chemokines, cytokines and growth factors.

2023年8月14日 · The ultimate fate of a thymocyte is determined by the specificity of its T cell receptor (TCR) for major histocompatibility complex (MHC) molecules during positive selection in the thymus, with...

thymocyte. Listen to pronunciation (THY-moh-site) A type of white blood cell. Thymocytes are part of the immune system and develop from stem cells in the bone marrow. They help protect the body from infection and may help fight cancer. Also called T cell and T lymphocyte.

In adult mice, the earliest thymocyte is bone-marrow-derived and exists within the double negative (DN) compartment, denoted by the absence of CD4 and CD8 surface expression [1,2]. The DN population can be further subdivided on the basis of CD44 and CD25 expression.

Thymocyte differentiation can be tracked by a number of membrane markers, as for example the TCR heterodimers, as well as the CD4 and CD8 molecules. The most immature thymocytes are TCR − CD4 − CD8 − (double negative for CD4 and CD8) and represent 3–5% of total thymocytes.

The thymus plays a crucial role in the development of T lymphocytes by providing an inductive microenvironment in which committed progenitors undergo proliferation, T-cell receptor gene rearrangements and thymocyte differentiate into mature T cells. ...

Thymocyte development is a multistep complex process and based on the surface expression of CD4 and CD8 molecules it is divided into three distinct stages. The early thymocytes are CD4 − CD8 − (double negative or DN) and are subdivided into DN1 (CD44 + 25 − ), DN2 (CD44 + 25 + ), DN3 (CD44 − 25 + ), and DN4 (CD44 − 25 − ) subsets.