Vinca alkaloids are a set of anti-mitotic and anti-microtubule alkaloid agents originally derived from the periwinkle plant Catharanthus roseus (basionym Vinca rosea) and other vinca plants. They block beta-tubulin polymerization in a dividing cell.

There are four major vinca alkaloids in clinical use: Vinblastine (VBL), vinorelbine (VRL), vincristine (VCR) and vindesine (VDS). VCR, VBL and VRL have been approved for use in the United States.

Vinca alkaloids (vincristine and vinblastine), as well as semisynthetic derivatives (vinorelbine, vindesine, and vinflunine), are potent antimitotic chemotherapeutics used to treat hematological and lymphatic neoplasms (Galindo-Solís and Fernández 2022).

The Vinca alkaloids have been widely incorporated into combination chemotherapy regimens for palliative and curative therapies, based not only on their lack of cross-resistance with drugs that alkylate DNA, but also on their distinct mechanism of action.

2024年3月10日 · Vinca alkaloids, which belong to a class of cell cycle phase M-specific anti-tubulin agents, were one of the first plant alkaloids to be developed for use as anti-cancer agents in humans.

A vinca alkaloid is a type of mitotic inhibitor and a type of antimicrotubule agent. A type of drug that blocks cell growth by stopping mitosis (cell division). Vinca alkaloids interfere with microtubules (cellular structures that help move chromosomes during mitosis).

There are four major vinca alkaloids in clinical use: Vinblastine (VBL), vinorelbine (VRL), vincristine (VCR) and vindesine (VDS). VCR, VBL and VRL have been approved for use in the United States.

Vinca alkaloids (Vas) are the phytochemicals that are naturally found in Catharanthus roseus and the well-known anticancer compounds include vinorelbine, vindesine, vincristine, and vinblastine. Currently around 64 varieties of C. roseus are screened for phytochemicals.

A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE.

2020年12月12日 · Vinca alkaloids are isolated from periwinkle plant (Vinca rosea, Catharanthus rosens). They possess anti-mitotic and anti-microtubule properties. Vinca alkaloids are structurally similar but have different therapeutic indications. They are the oldest group of …