Tropocollagen molecule: three left-handed procollagens (red, green, blue) join to form a right-handed triple helical tropocollagen. Collagen (/ ˈkɒlədʒən /) is the main structural protein in the extracellular matrix of the connective tissues of many animals. It is the most abundant protein in mammals, [1] making up 25% to 35% of protein content.

Tropocollagen, a collagen monomer, is a cylinder-shaped protein with a diameter of 15 Å and a length of 3000 Å that is made up of three α chains of polypeptide or peptide molecules having 100,000 Daltons each [13].

Tropocollagen is defined as the remodeled protein that results from the cleavage of amino acids from procollagen molecules during the process of exocytosis, leading to the formation of collagen fibrils in fibroblasts.

Tropocollagen refers to a subunit of collagen that is a triple helix structure made up of three polypeptide strands, spontaneously assembling into larger arrays in tissues with the help of hydrogen bonds and covalent cross-linking.

In animals, individual collagen triple helices, known as tropocollagen (TC), assemble in a complex, hierarchical manner that ultimately leads to the macroscopic fibers and networks observed in tissue, bone, and basement membranes .

…fragile and soluble form (tropocollagen). In time this soluble collagen changes to a more stable, insoluble form that can persist in tissues for most of an animal’s life. The rate of collagen synthesis is high in youth and declines throughout life, so that the ratio of insoluble to soluble… Read More; role in collagen formation

The large globular domains from both ends of the molecule are removed by C- and amino(N)-terminalproteinases to generate triple-helical type III collagen monomers called tropocollagen. In addition, crosslinks form between certain lysine and hydroxylysine residues.

2023年9月4日 · Enzymes known as collagen peptidases preform propeptide cleavage and remove the ends of the procollagen molecule and the molecule becomes tropocollagen

The tropocollagen spring mechanism allows collagen fibrils from some tissues to elongate significantly under small loads, and its recent discovery has the potential to change our fundamental understanding of how tissue deforms.

2021年7月21日 · Tropocollagen is the structural unit of a collagen fiber. It is made up of three polypeptide strands (referred to as alpha peptides) that are twisted together into a super helix or a right-handed triple helix. The amino acids in each chain are arranged in a regular pattern.