Intricacies of TGF-β signaling in Treg and Th17 cell biology
2023年5月23日 · Regulatory T (Treg) and Th17 cells are critical Th cell types involved in immune tolerance, homeostasis, pathogenicity, and pathogen clearance. It is therefore critical to understand how Treg...
Metabolic control of TH17 and induced Treg cell balance by an ... - Nature
2017年8月2日 · This study demonstrates the ability of a small molecule inhibitor to target a specific metabolic pathway, a finding which may lead to the development of novel therapeutics against TH17 mediated...
The Balance of Th17 versus Treg Cells in Autoimmunity
2018年3月3日 · T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial differentiation. However, terminally differentiated cells fulfill opposite functions: Th17 cells cause autoimmunity and inflammat …
The T reg /Th17 Cell Balance: A New Paradigm for Autoimmunity …
Th17 cells are derived from naïve CD4 + precursor cells and secrete a characteristic profile of cytokines including IL-17A, IL-17F, IL-21, and IL-22. Th17 cells have been shown to have a role...
The Balance of Th17 versus Treg Cells in Autoimmunity
2018年3月3日 · Th17 cells are thought to be the main driver of pathogenesis by initiating inflammation via activation of many cell types within the inflamed joint, including macrophages, DCs, and synoviocytes. Accumulated evidence suggests that the Th17/Treg balance underlies the pathogenic mechanisms driving autoimmune diseases [118,119].
Metabolism Controls the Balance of Th17/T-Regulatory Cells
2017年11月27日 · An appropriate balance between Th17 and Treg is a critical prerequisite for good health. Considering the close relationship between Th17 and Treg cells, and their plasticity, modulating the immunological balance between Th17 and Treg may represent a promising option for immune therapy.
Transcriptional and posttranslational regulation of Th17/Treg …
2021年7月28日 · Regulatory T (Treg) cells and T helper type 17 (Th17) cells play important roles in adaptive immune responses, antagonizing each other in immune disorders. Th17/Treg balance is critical to maintaining the immune homeostasis of human bodies and is tightly regulated under healthy conditions.
Review Th17 and regulatory T cell balance in autoimmune and ...
The immune response needs to be controlled to avoid a permanent immune response, and chronic inflammation. For that goal, there is a type of cells known to have suppressor activity …
Frontiers | The Alterations in and the Role of the Th17/Treg …
2021年7月11日 · Th17 and Treg cells represent two distinct phenotypes of CD4+ T cells with completely different functions. Th17 cells are proinflammatory, while Treg cells are anti-inflammatory. The balance established between these two subpopulations is crucial for preventing excessive immune activation, autoimmune responses, and metabolic syndrome pathogenesis.
The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut …
2015年12月17日 · Cytokine milieu orchestrates Treg and Th17 cell plasticity. Th17 cells lose stability in the absence of TGFβ and presence of IL-12, IL-23, and IL-1β, favoring IFNγ expression and differentiation into Th1/Th17 cells that produce …