Thioester - Wikipedia
In organic chemistry, thioesters are organosulfur compounds with the molecular structure R−C (=O)−S−R’. They are analogous to carboxylate esters (R−C (=O)−O−R’) with the sulfur in the thioester replacing oxygen in the carboxylate ester, as implied by the thio- prefix. They are the product of esterification of a carboxylic acid ...
2.12: Thioesters- Biological Carboxylic Acid Derivatives
2021年5月22日 · In the metabolism of lipids (fats and oils), thioesters are the principal form of activated carboxylate groups. They are employed as acyl carriers, assisting with the transfer of acyl groups such as fatty acids from one acyl X substrate to another. The ‘acyl X group’ in a thioester is a thiol.
21.8 Chemistry of Thioesters and Acyl Phosphates ... - Chemistry LibreTexts
2023年5月16日 · Acyl phosphates and acyl adenosine phosphates are not the only activated forms of carboxylate groups in biochemical reactions. Slightly lower on the reactivity scale are thioesters. In the metabolism of lipids (fats and oils), thioesters are the principal form of activated carboxylate groups.
Formation of thioesters by dehydrogenative coupling of thiols …
2020年9月28日 · Current methods for the synthesis of thioesters rely mostly on the acylation of thiols using stoichiometric acylating reagents, such as carboxylic anhydrides or acyl chlorides, in the presence of...
11.7: Hydrolysis of Thioesters, Esters, and Amides
2022年7月20日 · Acetylcholinesterase (EC 3.1.1.7), an enzyme present in the synapse, catalyzes hydrolysis of the ester group in acetylcholine, a neurotransmitter that triggers muscle contraction.
Structure, function, and regulation of thioesterases
2020年7月1日 · Thioesterases are present in all living cells and perform a wide range of important biological functions by catalysing the cleavage of thioester bonds present in a diverse array of cellular substrates.
21.8 Chemistry of Thioesters and Acyl Phosphates: Biological
Highlights. As mentioned in the chapter introduction, the substrate for a nucleophilic acyl substitution reaction in living organisms is generally either a thioester (RCOSR′) or an acyl phosphate (RCO 2 PO 32– or RCO 2 PO 3 R′ –).
Thioester - SpringerLink
Thioesters are esters in which the linking oxygen atom is replaced by sulfur. They are the product of dehydration reaction between a carboxylic acid derivative and a thiol. Thioesters are common intermediates in biochemistry, for example, in acetyl-CoA, malonyl-CoA, acetoacetyl-CoA, and propionyl-CoA. Thioesters are intermediates in several key ...
Introduction. In all living organisms, thioester formation is a common strategy to activate carboxylic acid building blocks, which are then fused with other chemical units, mostly by C–C bond formation, esterification, or amide bond formation (Figure 1A).
Thioesterase enzyme families: Functions, structures, and …
Thioesterases are enzymes that hydrolyze thioester bonds in numerous biochemical pathways, for example in fatty acid synthesis. This work reports known functions, structures, and mechanisms of updated thioesterase enzyme families, which are classified into 35 families based on sequence similarity.