Sphingosine - Wikipedia
Sphingosine (2-amino-4-trans-octadecene-1,3-diol) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.
Sphingosine | C18H37NO2 | CID 5280335 - PubChem
Sphingosine is a sphing-4-enine in which the double bond is trans. It has a role as a human metabolite and a mouse metabolite. It is a conjugate base of a sphingosine (1+). It is an enantiomer of a L-erythro-sphingosine. An amino alcohol with a …
Sphingosine - an overview | ScienceDirect Topics
Sphingosine is the major naturally occurring base present in sphingolipids. Carter and Humiston (1951) determined its structure (Table I) to be (D+) erythro- 1, 3-dihydroxy-2-amino-4-transoctadecene.
Sphingolipids and their metabolism in physiology and disease
2017年11月22日 · Sphingolipids represent one of the major classes of eukaryotic lipids. Historically, the first sphingolipids were isolated from brain in the late 19th century by Thudicum, who introduced the...
Sphingosine 1-phosphate: Lipid signaling in pathology and therapy
2019年10月18日 · Sphingosine 1-phosphate (S1P), a metabolic product of cell membrane sphingolipids, is bound to extracellular chaperones, is enriched in circulatory fluids, and binds to G protein–coupled S1P receptors (S1PRs) to regulate embryonic development, postnatal organ function, and disease.
Sphingosine: Uses, Interactions, Mechanism of Action - DrugBank …
2005年6月13日 · Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed) Be among the first to try our new AI-powered, …
Sphingosine - an overview | ScienceDirect Topics
Sphingosine is a crucial lysosphingolipid that is biologically very active and ubiquitously present in throughout the body. Sphingosine species including dihydrosphingosine (also called Sphinganine, d18:0) and sphingosine (d18:1) are the most abundant sphingosines in blood and cells.
Sphingosine 1-phosphate: lipid signaling in pathology and therapy
Sphingosine 1-phosphate (S1P), a metabolic product of cell membrane sphingolipids, is bound to extracellular chaperones, enriched in circulatory fluids and binds to G protein-coupled S1P receptors (S1PRs) to regulate embryonic development, postnatal organ function and disease.
Sphingosine - an overview | ScienceDirect Topics
Sphingosine is an 18-carbon amino dialcohol with an unsaturated hydrocarbon chain. Sphingosine is the structure that defines sphingolipids (Fig. 5.13). Sphingosine is synthesized through the union of palmitic acid (palmitoyl-CoA) and the amino acid serine by condensation.
Sphingosine-1-Phosphate Signaling in Immune Cells and …
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cell processes. It is produced by the phosphorylation of sphingosine by sphingosine kinases (SphKs) and exported out of cells via transporters such as spinster homolog 2 (Spns2).