The technological landscape and applications of single-cell multi-omics …
2023年6月6日 · Single-cell multi-omics technologies and methods characterize cell states and activities by simultaneously integrating various single-modality omics methods that profile the transcriptome,...
Single-cell omics: Overview, analysis, and application in biomedical ...
Single-cell sequencing methods provide the highest resolution insight into cellular heterogeneity. Owing to their rapid growth and decreasing cost, they are now widely accessible to scientists worldwide. Single-cell technologies enable analysis of a large number of cells, making them powerful tools …
Single-cell omics - Nature
2023年5月31日 · Single-cell omics approaches are providing unprecedented insights into cellular function and dysfunction. This Editorial highlights the remarkable potential of these technologies...
Transformers in single-cell omics: a review and new perspectives
2024年8月9日 · Here we first describe the transformer architecture and its single-cell adaptations and then present a comprehensive review of the existing applications of transformers in single-cell...
Single-cell omics: experimental workflow, data analyses and ...
Single-cell omics represent a groundbreaking advancement in the biomedical field, offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section.
Single Cell Atlas: a single-cell multi-omics human cell …
2024年4月19日 · Here, we construct a single-cell multi-omics map of human tissues through in-depth characterizations of datasets from five single-cell omics, spatial transcriptomics, and two bulk omics across 125 healthy adult and fetal tissues.
Single-cell omics: A new direction for functional genetic research …
Over the past decade, with the development of high-throughput single-cell sequencing technology, single-cell omics has been emerged as a powerful tool to understand the molecular basis of cellular mechanisms and refine our knowledge of diverse cell states.
Single-Cell Omics: An Overview - ScienceDirect
2019年1月1日 · Single-cell omics is the profiling of single cells sampled from heterogeneous population of cells from different cellular states, where the normal development and disease processes can be studied and dissected at a single-cell resolution.
Spatiotemporal omics for biology and medicine - Cell Press
2024年8月22日 · Large-scale single-cell omics initiatives such as the Human Cell Atlas 147 and Human BioMolecular Atlas Program (HuBMAP) 148 compiled single-cell datasets spanning diverse human tissues and organs.
Single-Cell Multiomics Analysis for Drug Discovery - PMC
In this review, we discuss the value of multiomics in drug discovery and the importance of single-cell multiomics measurements. We will provide examples of the benefits of applying single-cell omics technologies in drug discovery and development.
Single-cell omics: experimental workflow, data analyses and
Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.
Methods and applications for single-cell and spatial multi-omics
2023年3月2日 · In this Review, we highlight advances in the fast-developing field of single-cell and spatial multi-omics technologies (also known as multimodal omics approaches), and the computational...
scTrends: A living review of commercial single-cell and ... - Cell …
2 天之前 · De Jonghe et al. present a comprehensive review of current commercial single-cell and spatial omic technologies, outlining key platforms, methodologies, and trends shaping the field—from microfluidics and plate-based approaches to combinatorial indexing, highlighting their applications in drug discovery. The authors discuss emerging engineering and computational …
HOME | Single Cell Atlas
Single Cell Atlas (SCA) is a single-cell multi-omics atlas presenting comprehensive overview of healthy human tissues, accompanied by a series of bioinformatics tools to aid scientists with their omics analyses.
Single Cell Atlas: a single-cell multi-omics human cell encyclopedia
2024年4月19日 · Here, we construct a single-cell multi-omics map of human tissues through in-depth characterizations of datasets from five single-cell omics, spatial transcriptomics, and two bulk omics across 125 healthy adult and fetal tissues.
Single-Cell Multiomics Techniques: From Conception to …
In this review, we cover recent advances in sc-multiomics technologies and focus on methods that simultaneously profile the genome, epigenome, and/or transcriptome in single cells. We further discuss their current and potential applications towards understanding gene regulation in development and disease.
Machine learning for perturbational single-cell omics - Cell Press
We first propose a general set of objectives of perturbation modeling for single-cell omics in order to contextualize current approaches, as well as datasets that address these objectives. We then discuss future directions of the emerging field, which center around effectively leveraging DL.
Single-Cell Omics
The ELIXIR Single-Cell Omics (SCO) Community aims to identify the main challenges in single-cell and spatial omics and coordinate an international effort to best serve researchers needs, building on top of national experiences and paving the way towards integrated long-term solutions for SCO research.
Advances in single-cell omics and multiomics for high-resolution ...
2024年3月5日 · Single-cell omics studies enable the analysis of individual cells and reveal diverse cell types, dynamic cellular states, and rare cell populations. These techniques...
Integration Analysis of Single-Cell Multi-Omics Reveals ... - PubMed
Prostate cancer (PCa) is an extensive heterogeneous disease with a complex cellular ecosystem in the tumor microenvironment (TME). However, the manner in which heterogeneity is shaped by tumors and stromal cells, or vice versa, remains poorly understood. In this study, single-cell RNA sequencing, sp …
Quantum Leap in Single Cell Genomics: Scale Bio ... - Business Wire
2024年8月14日 · Release Summary. Scale Bio is launching the ‘100 Million Cell Challenge’ in collaboration with Ultima Genomics and NVIDIA, pushing the boundaries of single cell omics.
Single-Cell Multi-omic Integration Compares and Contrasts ... - Cell …
2019年6月7日 · Defining cell types requires integrating diverse single-cell measurements from multiple experiments and biological contexts. To flexibly model single-cell datasets, we developed LIGER, an algorithm that delineates shared and dataset-specific features of cell identity.
Interpreting single-cell and spatial omics data using deep neural ...
2024年12月4日 · Single-cell and spatial omics datasets can be organized and interpreted by annotating single cells to distinct types, states, locations or phenotypes. However, cell annotations are inherently ...
BD ® OMICS-One Immune Profiler Protein Panel - BD Biosciences
The BD ® OMICS-One Immune Profiler Protein Panel (BD ® OMICS-One IP Protein Panel) is developed using our antibody-oligo based technology and consists of 30 different specificities against most major human immune markers lyophilized in a single tube.. Designed and optimized to work on the BD Rhapsody ™ Single-Cell Analysis System, the BD ® OMICS-One IP Protein …
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