Safrole - Wikipedia
Safrole is an organic compound with the formula CH 2 O 2 C 6 H 3 CH 2 CH=CH 2. It is a colorless oily liquid, although impure samples can appear yellow. A member of the phenylpropanoid family of natural products, it is found in sassafras plants, among others.
What is the story behind the banning of Safrole?
Official Reason behind the banning of Safrole. In the 1950s in a government study, Safrole had been force fed to rats over a long period of time and had been shown to cause cancer in those rats. What is the controversy?
Safrole | C10H10O2 | CID 5144 - PubChem
Safrole is the toxic agent in sassafras oil; Safrole is classified as 2B (possible human carcinogen) by IARC; Safrole is metabolized in the body to 1'-hydroxysafrole; Ingestion of 5 ml of sassafras oil can cause severe symptoms (tachycardia, hypotension, and respiratory paralysis) or death; Large doses may damage the liver; Drinking 10 cups of ...
The Ultimate Guide to Safrole
Safrole is a natural organic compound that belongs to the class of allylbenzenes. It is found in the roots, bark, and fruits of certain plants, including sassafras, cinnamon, nutmeg, and camphor. Safrole is known for its sweet, spicy, and woody odor, which makes it a popular flavoring agent in food and beverages.
Why Is Sassafras Banned? - MedicineNet
The roots and barks of the sassafras tree contain a high concentration of the chemical named safrole. Safrole was listed as a carcinogen in rats by the Food and Drug Administration (FDA) and is hence banned at present.
Safrole - an overview | ScienceDirect Topics
Safrole, the main component of oil of sassafras, is widely used as a flavoring agent in drugs and in the manufacture of heliotropin, perfumes, soaps, and piperonyl butoxide (a compound used in a variety of insecticides to enhance the pesticidal properties of other active ingredients).
Sassafras Drug: What It Feels Like and Comparison to Molly - Healthline
Jul 28, 2023 · Safrole, a precursor to the sassafras drug, is classified as a cancer-causing substance. It’s been linked to liver cancer and tumor growth in animal studies.
Review on safrole: identity shift of the ‘candy shop’ aroma to a ...
Safrole, a phenylpropene with a ‘candy shop’ aroma, is abundant in nature among diverse plant genera such as Sassafras, Ocotea, Cinnamomum, Myristica, and Piper. Sassafras oil has been used extensively for a long time, first by Native Americans and later by European settlers in traditional medicine and as a flavouring agent.
Safrole - 15th Report on Carcinogens - NCBI Bookshelf
Dec 21, 2021 · Safrole is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. Safrole caused liver tumors in two rodent species and by two different routes of exposure.
Safrole - SpringerLink
Jun 5, 2024 · Safrole, also known as 4-allyl-1,2-methylenedioxybenzene, is a transparent or slightly yellow, viscous liquid with widespread applications in cosmetics and food flavoring. It is derived from sassafras oil, extracted from the root-bark or fruit of sassafras plants belonging to the Lauraceae family.
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