Rap1 signaling pathway - Homo sapiens (human) - GenomeNet
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation.
Rap1 signalling: adhering to new models - Nature
Control of the ERK pathway. Rap1 binds to the serine/threonine kinase Raf1 in vitro, through an interaction with both the RBD and the adjacent cysteine-rich region of Rap1 (Refs 37,38) and, in ...
Rap1 regulates hematopoietic stem cell survival and affects
2019年12月13日 · We show that RAP1 interacts with many members of the DNA damage response (DDR) pathway. RAP1 depleted cells show reduced interaction between XRCC4/DNA Ligase IV and DNA-PK, and are impaired in...
PATHWAY: ko04015 - KEGG
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
KEGG PATHWAY: mmu04015
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
PATHWAY: map04015 - KEGG
Rap1 signaling pathway. Description. Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation.
Rap1: a key regulator in cell-cell junction formation
2007年1月1日 · Recently, the Rap1 signalling pathway has been found to play a crucial role in the regulation and maintenance of cell-cell contacts. The present review focuses on the evidence that led to the appreciation of Rap1 as a master regulator of cell-cell junctions.
Distinct functions for Rap1 signaling in vascular morphogenesis …
Rap1 promotes angiogenic responses to VEGF by promoting VEGF Receptor 2 (VEGFR2) activation, in part via integrin α v β 3. Rap1 also acts downstream from VEGF, FGF2 and S1P receptors in signaling pathways leading to EC migration, proliferation, tube formation, and regulation of vascular permeability.
Rap1-GTPases control mTORC1 activity by coordinating lysosome ... - Nature
2020年3月17日 · We find that when amino acids are limited, the Rap1-GTPases confine lysosomes to the perinuclear region and reduce lysosome abundance, which suppresses mTORC1 signaling. Rap1 activation,...
Regulation of immune responses and hematopoiesis by the Rap1 signal
Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
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