Nuclear receptor - Wikipedia
Nuclear receptors are multifunctional proteins that transduce signals of their cognate ligands. Nuclear receptors (NRs) may be classified into two broad classes according to their mechanism of action and subcellular distribution in the absence of ligand.
Nuclear receptors: from molecular mechanisms to therapeutics
Nuclear receptors are classically defined as ligand-activated transcription factors that regulate key functions in reproduction, development, and physiology. Humans have 48 nuclear receptors, which when dysregulated are often linked to diseases.
The nuclear receptor superfamily: A structural perspective
Nuclear receptors (NRs) are a family of transcription factors that regulate numerous physiological processes such as metabolism, reproduction, inflammation, as well as the circadian rhythm. NRs sense changes in lipid metabolite levels to drive ...
Nuclear Receptor - an overview | ScienceDirect Topics
A Nuclear Receptor is a monomeric protein that is involved in modifying gene transcription by binding to specific DNA sequences called hormone response elements, which leads to changes in gene expression within the nucleus. AI generated definition based on: Handbook of Pharmacogenomics and Stratified Medicine, 2014
Structural overview and perspectives of the nuclear receptors ...
The nuclear receptors (NRs) are an evolutionarily related family of transcription factors, which share certain common structural characteristics and regulate the expressions of various genes by recognizing different response elements.
Nuclear Receptors - PMC - National Center for Biotechnology ...
Overview: Nuclear receptors are specialised transcription factors with commonalities of sequence and structure, which bind as homo- or heterodimers to specific consensus sequences of DNA (response elements) in the promoter region of particular target genes. They regulate (either promoting or repressing) transcription of these target genes in ...
Nuclear receptors: overview and classification - PubMed
The nuclear receptor superfamily comprises a large group of transcription factors that play a key regulatory role in development and homeostasis of multicellular organisms. A special feature of nuclear receptors is their ability to bind to condensed …