How does multistep tumorigenesis really proceed? - PMC
Evidence is accumulating that both normal and fully neoplastic cell populations harbor subpopulations of stem cells (SCs) that can both self-renew and spawn more differentiated progeny. In the context of cancer, neoplastic SCs are proposed to hold most, if not all of the tumor-initiating potential.
Tumor initiation and early tumorigenesis: molecular mechanisms …
2024年6月19日 · Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event.
How does multistep tumorigenesis really proceed? - PubMed
An emerging concept, proposed here, states that cancer stem cells, key players in cancer initiation and metastasis, arise when transit-amplifying cells with mutant genomes dedifferentiate and enter the stem cell state.
Multi-step Tumorigenesis and Genome Instability
2021年7月6日 · The characterization of the growth of primary and metastatic tumors is crucial for the diagnosis and therapy of cancer. The process of tumorigenesis comprises multiple steps of mutations in cancer driver genes that provide the cell clone with a selective growth...
Evasion of anti-growth signaling: a key step in tumorigenesis and ...
Carcinogenesis is a complex, stochastic and yet highly coordinated multi-step process in which normal cells progress through hyperplasia to mild, ... In prostate cancer cells, KLF5 has been shown to suppress tumorigenesis in xenograft models, and the suppression was suggested to require ERβ and its association with KLF5 and the transcription ...
Pathways to Tumorigenesis—Modeling Mutation Acquisition in …
It is widely accepted that tumorigenesis is a multistep process, the progression of which depends on a sequential accumulation of mutations within tissue cells. Although tumor cells often exhibit a large number of mutations [1,2], only a relatively small subset is crucial for neoplastic development [2–6].
Recent advances in research on multistage tumorigenesis
2000年6月6日 · In this review we summarize recent advances in cancer research that have provided new insights in the molecular mechanisms underlying the transition between one tumour stage and the next and into...
The evolution of the cancer niche during multistage …
2013年6月13日 · In this Perspectives article, we propose the novel concept that the tumour microenvironment is built through rate-limiting steps during multistage carcinogenesis.
Tumor initiation and early tumorigenesis: molecular mechanisms …
2024年6月19日 · Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic mutations and clonal expansion in normal tissues, their transformation into cancer remains a rare event, indicating the presence of add …
How Does Multistep Tumorigenesis Really Proceed?
2015年1月11日 · An emerging concept, proposed here, states that cancer stem cells, key players in cancer initiation and metastasis, arise when transit-amplifying cells with mutant genomes dedifferentiate and enter...
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