Mannose-Binding Lectin: Biologic Characteristics and Role in the ...
The mannose-binding lectin (MBL) is a protein of the innate immune system, belonging to the collectin family, able to deploy a variety of antimicrobial activities. It recognizes and binds various pathogens (including bacteria, viruses, fungi, and parasites), providing protection against the microbial invasion of the host [ 1 ].
The role of mannose-binding lectin in health and disease
Mannose-binding lectin (MBL) is a pattern recognition molecule of the innate immune system. It belongs to the collectin family of proteins in which lectin (carbohydrate-recognition) domains are found in association with collagenous structures.
Mannose-binding lectin deficiency - MedlinePlus
Mannose-binding lectin deficiency is a condition that affects the immune system. People with this condition have low levels (deficiency) of an immune system protein called mannose-binding lectin in their blood.
Mannose-Binding Lectin Levels in Critically Ill Children with …
A critical antimicrobial protein in this pathway is mannose-binding lectin (MBL) which recognizes mannose sugars on the periphery of bacteria, viruses, and fungi, and on damaged human cells. ( 1 , 2 ) Binding of this protein to cell membranes causes conformational changes that activate directed complement deposition for the invading microbe to ...
Clinical manifestations of mannan-binding lectin deficiency
Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10% of the general population may, depending on definition, be ...
Mannose-binding lectin: structure, function, genetics and …
Mannose-binding lectin (MBL), a serum protein characterised by both collagenous regions and lectin domains, plays an important role in innate immune defence.
Mannose Binding Lectin - an overview | ScienceDirect Topics
Mannose binding lectin (MBL) is a host protein that recognizes specific carbohydrate patterns on the surfaces of various microorganisms and can initiate the complement lectin pathway leading to opsonization, phagocytosis and lysis of targeted pathogens.
Mannose-binding lectin and the balance between immune
A pivotal link between the innate immune system and other functions is mannose-binding lectin (MBL), a pattern recognition molecule. Multiple studies have demonstrated that MBL deficiency increases susceptibility to infection, and the mechanisms associated with this susceptibility to infection include reduced opsonophagocytic killing and ...
Mannose-Binding Lectin in Human Health and Disease
Mar 13, 2021 · Mannose-binding lectin (MBL) plays, as a soluble pattern recognition molecule, a central role in the innate immune response. MBL binds to the surface of carbohydrates on a wide variety of pathogens and mediates opsonophagocytosis via activation of the lectin...
Mannose-binding lectin and the balance between immune …
A pivotal link between the innate immune system and other functions is mannose-binding lectin (MBL), a pattern recognition molecule.
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