IGFBP-1 in cancer: expression, molecular mechanisms, and …
In this review, we provided an overview of IGFBP-1 in normal physiology, and its aberrantly expression and the underlying molecular mechanisms in a range of common tumors, as well …
Regulation of IGFBP-1 in Metabolic Diseases - PMC
Insulin-like growth factor binding proteins (IGFBPs) play a key role in insulin and insulin growth factor signaling and are known to be expressed in several tissues. Studies on the …
IGF-Binding Proteins: Why Do They Exist and Why Are There So …
2018年4月8日 · In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF-binding protein (IGFBP) family, of which six distinct types exist. These …
The insulin like growth factor and binding protein family: Novel ...
In this review, we discuss the experimental data indicating a critical role for IGF/IGFBP axis in metabolic regulation. We highlight key discoveries through which IGFBPs have emerged as …
Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3 ... - PubMed
2020年5月5日 · Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an …
IGF binding proteins in cancer: mechanistic and clinical insights
2014年4月10日 · The insulin-like growth factor (IGF) binding proteins (IGFBPs) are a family of six proteins that function as transport proteins for IGF-I and IGF-II in the circulation and also...
The insulin-like growth factor-binding protein (IGFBP) superfamily
Over the last decade, the concept of an IGFBP family has been well accepted, based on structural similarities and on functional abilities to bind IGFs with high affinities. The existence of other …
Expression characteristics and their functional role of IGFBP gene ...
2023年4月24日 · Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in …
Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases
2018年8月29日 · Insulin-like growth factor binding proteins (IGFBPs) are a group of secreted proteins which serve as transport proteins for insulin-like growth factors (IGFs) with high …
Structural basis for assembly and disassembly of the IGF/IGFBP…
2022年7月30日 · Here, we report cryo-EM structure of the human IGF1/IGFBP3/ALS ternary complex, revealing the detailed architecture of a parachute-like ternary complex and crucial …
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