If Channel as an Emerging Therapeutic Target for Cardiovascular ...
The funny channel is a good target for the development of new drugs as it generates spontaneous activity and controls the heart rate by acting specifically on the cardiac rate control and pacemaker rhythm.
Pacemaker current - Wikipedia
The pacemaker current (If, or IKf, also called funny current) is an electric current in the heart that flows through the HCN channel or pacemaker channel. Such channels are important parts of the electrical conduction system of the heart and form a component of the natural pacemaker.
Ivabradine – the first selective sinus node If channel inhibitor in …
Ivabradine is the first specific heart rate-lowering agent that has completed clinical development for stable angina pectoris. It is selective for the If current, lowering heart rate at concentrations that do not affect other cardiac ionic currents.
The therapeutic role of ivabradine in heart failure - PMC
Ivabradine enters the I f channel and binds to its intracellular side, subsequently disrupting the mixed sodium and potassium ion current flow through the channel. This prolongs the slow spontaneous phase of diastolic depolarization, and thereby reduces HR.
If Channel as an Emerging Therapeutic Target for Cardiovascular ...
2017年11月24日 · Currently, funny channel inhibition is being targeted for the treatment and prevention of cardiovascular diseases such as atherosclerosis and stroke. A selective I f channel inhibitor named ivabradine was discovered for clinical use in …
Ivabradine (Corlanor) for Heart Failure: The First Selective and ...
Ivabradine is a heart-rate-lowering agent that acts by selectively and specifically inhibiting the cardiac pacemaker current (If), a mixed sodium-potassium inward current that controls the spontaneous diastolic depolarization in the sinoatrial (SA) node and hence regulates the heart rate. 12,13 The molecular channel belongs to the HCN family. 10...
If Channel as an Emerging Therapeutic Target for Cardiovascular ...
2017年11月24日 · Currently, funny channel inhibition is being targeted for the treatment and prevention of cardiovascular diseases such as atherosclerosis and stroke. A selective If channel inhibitor named...
Review of the If selective channel inhibitor ivabradine in the ...
A new antiangina drug, ivabradine, has been developed and licensed for clinical use. It exclusively reduces the heart rate by selectively blocking the I(f) channel of the sino-atrial node.
Heart Rate Reduction by If-Channel Inhibition and its Potential …
2009年7月1日 · If -channel inhibition mainly reduces HR, thereby improving myocardial oxygen supply, energy balance, and cardiac function. Ivabradine was well tolerated and revealed a good safety profile in the investigated study populations.
Frontiers | If Channel as an Emerging Therapeutic Target for ...
2017年11月23日 · In the search for such drugs, almost four decades ago the I f channel, also known as the “funny channel,” emerged as a novel site for the selective inhibition of heart rate. These I f channels, with a mixed sodium and potassium inward current, have been identified in the sinoatrial node of the heart, which mediates the slow diastolic ...