Epithelial Stem Cells: Turning over New Leaves - PMC - PubMed …
In this review, we will focus on four well-characterized epithelial stem cells whose tissues possess diverse architectural designs and physiology: intestine, epidermis, mammary gland, and cornea.
Epithelial Stem Cells: Making, Shaping and Breaking the Niche
2022年1月19日 · Taking examples of epithelial stem cells from a range of model organisms and tissues, we will discuss the roles of stem cell progeny, autocrine stem cell signals and stem cell regulation of the niche in tissue homeostasis and repair.
Most epithelial tissues self-renew throughout adult life due to the presence of multipotent stem cells and/or unipotent progenitor cells. Epithelial stem cells are specified during devel-opment and are controlled by epithelial-mesenchymal interactions.
Epithelial Stem Cells - Institute for Regenerative Medicine
These vital barriers are replenished by epithelial stem cells. IRM researchers study epithelial stem cells throughout the body to find ways to improve wound healing, heal the lungs after viral infection, reverse baldness, and more.
Defining the identity and the niches of epithelial stem cells with ...
2023年11月20日 · By characterizing cortical and medullary compartments in the human thymus at single-cell resolution, in this study we have defined specific epithelial populations, including those that share properties with bona fide stem cells (SCs) of lifelong regenerating epidermis.
Epithelial stem cell culture: modeling human disease and …
However, recent technical advances in epithelial stem cell culture have led to the development of novel in vitro strategies for regenerating epithelial tissues and for closely mimicking human diseases such as cancer and inflammation.
Stem cells of the skin epithelium - PMC
Skin epithelial stem cells represent a ripe target for research into the fundamental mechanisms underlying these important processes. The skin is the first line of defense to protect the body from dehydration, injury, and infection.
Epithelial stem cells: turning over new leaves - PubMed
2007年2月9日 · Despite morphological and functional differences among epithelia, common signaling pathways appear to control epithelial stem cell maintenance, activation, lineage determination, and differentiation. Additionally, deregulation of these pathways can lead to human disorders including cancer.
Epithelial stem cells - PubMed
It is likely that adult epithelial stem cells will be useful in the treatment of diseases, such as ectodermal dysplasias, monilethrix, Netherton syndrome, Menkes disease, hereditary epidermolysis bullosa, and alopecias. Additionally, other skin problems such as burn wounds, chronic wounds, and ulcers will benefit from stem cell-related therapies.
Plasticity of epithelial stem cells in tissue regeneration | Science
2014年6月13日 · Stem cells are very important in the maintenance of our bodies' tissues and organs. Blanpain and Fuchs review how different populations of naturally lineage-restricted epithelial stem cells and committed progenitors can also display remarkable plasticity.
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