Epidermal growth factor receptor - Wikipedia
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
Biochemistry, Epidermal Growth Factor Receptor - StatPearls
2023年12月3日 · The epidermal growth factor receptor (EGFR) family is a subclass of receptor tyrosine kinase (RTK) proteins and consists of 4 members: EGFR (ErbB1, HER1), ErbB2 (HER2, neu in rodents), ErbB3 (HER3) and ErbB4 (HER4).
Estimated Glomerular Filtration Rate (eGFR) - The National Kidney ...
2024年10月15日 · eGFR of 90 or higher is in the normal range; eGFR of 60 -89 may mean early-stage kidney disease; eGFR of 15 -59 may mean kidney disease; eGFR below 15 may mean kidney failure; What is a normal eGFR number? In adults, the normal eGFR number is usually more than 90. eGFR declines with age, even in people without kidney disease.
Estimated Glomerular Filtration Rate (eGFR) - Cleveland Clinic
2021年6月17日 · Healthcare providers use estimated glomerular filtration rate (eGFR) to determine if you have kidney disease, and if so, what stage. eGFR measures your kidneys’ ability to filter toxins or waste from your blood. A very low number may indicate kidney failure, which requires dialysis or a kidney transplant. Find a Primary Care Provider.
Epidermal growth factor receptor (EGFR): A rising star in the era of ...
EGFR is a receptor protein that spans the cell membrane. TKI consists of N lobe and C lobe. EGFR-TKI competes with ATP for inhibition of this site. If the growth factor (ligand) binds to the receptor, it forms an asymmetric dimer. A variety of proteins associated with the phosphorylation of tyrosine, the downstream protein is constantly ...
Epidermal growth factor - Wikipedia
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa [5] and has 53 amino acid residues and three intramolecular disulfide bonds. [6] EGF was originally described as a secreted peptide found in the submaxillary glands of mice and in human urine.
Review on Epidermal Growth Factor Receptor (EGFR) Structure ... - PubMed
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its …
EGFR gene - MedlinePlus
The EGFR gene provides instructions for making a receptor protein called the epidermal growth factor receptor, which spans the cell membrane so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. Learn about this gene and related health conditions.
The epidermal growth factor receptor pathway in chronic …
2016年7月4日 · The epidermal growth factor receptor (EGFR) pathway has a crucial role in renal physiology, development, tissue repair and electrolyte handling. Experimental studies have provided...
A comprehensive pathway map of epidermal growth factor …
2005年5月25日 · The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells.