The development of the cerebral cortex, known as corticogenesis is the process during which the cerebral cortex of the brain is formed as part of the development of the nervous system of mammals including its development in humans. The cortex is the outer layer of the brain and is composed of up to six layers.

2021年10月6日 · By comparing the regulatory landscapes of different cortical areas during development (V1 and PFC), we found distinct sets of transcription factor binding motifs that were differentially...

Cortical Development Inc has been established as a non-profit entity to foster academic collaboration and promote the dissemination of new knowledge pertaining to cerebral cortical development and related neurodevelopmental disorders. The primary function is to create a scientific meeting every three years. A meeting, titled: Cortical Dev

2023年2月15日 · Mutations of human-specific genetic modifiers of corticogenesis have started to be linked to neurodevelopmental disorders, providing evidence for their physiological relevance and suggesting...

2023年10月13日 · Cortical development in humans is a meticulously regulated process that unfolds over months of prenatal and years of postnatal life. This process encompasses the genesis, differentiation, and maturation of various cellular lineages that are critical to the complex structure and function of the brain and are affected in neurodevelopmental ...

Development of the cerebral cortex involves an intricate sequence of genetically regulated steps that is orchestrated by transcription factors. The nature and size of cortical regions is regulated by secreted molecules, such as Bmp, Fgf, RA, Shh and Wnt, often produced by patterning centers.

2024年1月1日 · Cortical development typically refers to the process by which the cerebral cortex is formed in mammals. The development of the cerebral cortex shares some common features with other cortical structures, such as the cerebellum. However, some aspects of the development of the cerebral cortex are unique to this structure, the highest-order ...

1997年4月1日 · The cortex is first visible in development as a thin layer of subpial cells known as the preplate (Figure 2a). Next, the cells that will form the deepest cortical layer, layer VI, migrate to the preplate, which they penetrate and split into two layers: an upper marginal zone and a …

2024年5月23日 · We argue that desynchronization of network activity is a fundamental step through which the cortex transitions from passive, bottom–up detection of sensory stimuli to active sensory processing...

This book reviews recent progress in cortical development research, focusing on the mechanisms of neural stem cell regulation, neuronal diversity and connectivity formation, and neocortical organization.