2021年6月21日 · Chordomas are malignant tumors of primitive notochordal origin that most commonly occur in the sacrum and coccyx. The tumor typically presents in patients > 50 years of age with insidious low back pain with bowel or bladder dysfunction.

More efforts have been made on accumulating evidence of the notochordal origin of chordoma, discovering signaling pathways and identifying crucial targets in chordomagenesis. In this review, we summarize the most recent research findings and focus on the pathophysiology and molecular mechanisms of chordoma.

Chordoma is the most frequent primary tumor of the mobile spine. Due to slow growth, both initial symptoms and recurrences after treatment arise later, making it difficult to evaluate the effectiveness of treatment protocols. A prospective series of 37 cases is compared with a retrospective group of 15 patients observed between 1954 and 1991.

Chordoma is a rare low-grade primary malignant skeletal tumor, which is presumed to derive from notochord remnants. The pathogenesis of chordoma has not been fully elucidated. However, recent advances in the molecular biolo-gy studies have identified brachyury underlying the initiation and progression of chordoma cells.

Chordomas are relatively rare, slow-growing, primary malig-nant bone tumors. They are thought to arise from notochordal remnants and thus they occur along the mid-line from the skull base to the sacrum.

New photon beam techniques, e.g. intensity modulated radiation therapy and stereotactic procedures, have recently been evaluated. Although less available than photons, hadrons possess certain advantages. While chemotherapy is poorly active, recent interest has focused on molecular-targeted agents.

2024年9月10日 · Chordomas are uncommon malignant tumours of the axial skeleton that account for 1% of intracranial tumours and 4% of all primary bone tumours. They originate from embryonic remnants of the primitive notochord (earliest fetal axial skeleton, extending from the Rathke's pouch to the tip of the coccyx).

A chordoma is a very rare form of primary bone cancer, accounting for approximately 8% of all primary tumours arising in the bone. This information has been written for patients, their families and friends and the general public to help them understand more about a rare form of primary bone cancer, known as chordoma.

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Objective: Chordoma is a rare neoplasm of the neuraxis derived from remnants of the primitive notochord. The importance of wide margins and use of adjuvant therapy in spinal chordomas are still contentious points in the management of spinal chordomas.

Chordomas typically occur in the spine or the base of the skull, and they can cause pain and neurological symptoms due to compression of adjacent tissues. Chordoma is the fourth most common primary bone tumor and accounts for about 3% of …

2022年12月5日 · Background and etiopathology Chordoma is a relatively rare malignant midline tumor arising in the axial skeleton, primarily at its cranial and caudal ends, that is derived from persistent...

2021年6月21日 · Periosteal Chondromas are rare, benign, chondrogenic tumors that occur on the surface of long bones, most commonly the proximal humerus. Patients typically present between the ages of 10 and 20 years of age with regional pain secondary to irritation of overlying tendons.

2012年10月30日 · This video reviews the characteristic histology of a chordoma? 1) Does this video accurately demonstrate what a physaliferous cell looks like? Yes

Chordoma is an uncommon malignant tumor with unusual characteristics developing in the remnants of the notochord and usually manifesting itself in patients in their forties and fifties. It is usually located in the body's symmetrical axis or attached to it.

Our study clearly demonstrates that surgery significantly improves the overall survival for patients with chordoma. We have further identified age <59 and size of primary tumor <8 cm as important prognostic factors determining the outcome with substantial statistical significance.

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Sacrococcygeal chordoma presents a difficult diagnostic and therapeutic problem, with a high rate of local recurrence. The purpose of this report is to define the importance of adequate surgical treatment for optimum outcome and survival. Fifty-two patients underwent surgical treatment for sacrococcygeal chordoma between 1980 and 2001.

Chordoma is a rare tumor, and its natural history is still not well known. All patients affected by localized chordoma surgically treated at Istituto Ortopedico Rizzoli, Bologna, and Istituto Nazionale Tumori, Milan, Italy, between 1980 and 2008 were reviewed.