Endocytosis via caveolae: alternative pathway with distinct …
Nowadays, it is generally accepted that caveola-mediated endocytosis functions as a true uptake mechanism parallel to the clathrin-mediated pathway. Being ligand-triggered, caveolar endocytosis provides a more selective and highly regulated way for …
Caveolae and the regulation of endocytosis - PubMed
Although clathrin-mediated endocytosis constitutes the main pathway for internalization of extracellular ligands and plasma membrane components it has generally been accepted that other uptake mechanisms-caveolae-mediated and noncaveolar raft-dependent endocytosis-also exist.
Caveolae - Wikipedia
Caveolae are one source of clathrin-independent raft-dependent endocytosis. The ability of caveolins to oligomerize due to their oligomerization domains is necessary for formation of caveolar endocytic vesicles.
Key principles and methods for studying the endocytosis of
2021年3月12日 · Caveolae: limited evidence for nanoparticle uptake. An extensive literature links caveolae to endocytosis.
Deciphering the relationship between caveolae-mediated …
2022年9月1日 · The caveolae-mediated transport across polarized epithelial cell barriers has been largely deciphered in the last decades and is considered the second essential intracellular transfer mechanism, after the clathrin-dependent endocytosis.
Caveolae as plasma membrane sensors, protectors and organizers
2013年1月23日 · Caveolae at the plasma membrane can be removed by endocytosis to regulate their surface density or can be disassembled and their structural components degraded.
Endocytosis: a pivotal pathway for regulating metastasis
2020年12月2日 · The endocytosis of specific cargoes via specific receptors can take place by clathrin-mediated (CME), caveolae-mediated (CavME), clathrin- and caveolae-independent endocytic (CLIC/GEEC)...
Endocytosis - The Cell - NCBI Bookshelf
In contrast to phagocytosis, which plays only specialized roles, pinocytosis is common among eukaryotic cells. The best-characterized form of this process is receptor-mediated endocytosis, which provides a mechanism for the selective uptake of specific macromolecules (Figure 12.36).
Caveolae/raft-dependent endocytosis - PMC
In this review, we argue that caveolae and rafts mediate a common endocytic pathway, caveolae/raft-dependent endocytosis, defined by its clathrin independence, dynamin dependence, sensitivity to cholesterol depletion, and the morphology and lipid composition of …
Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate
2014年4月8日 · Caveolins and cavins are crucial components of caveolae, specialized microdomains that also constitute an endocytic route. Here we show that specific caveolar proteins are independently acting negative regulators of clathrin-independent endocytosis.