Bile acid transporters: structure, function, regulation and ... - PubMed
Cytosolic ileal bile acid binding protein (IBABP) mediates the transcellular movement of bile acids to the basolateral membrane across which they exit the cells via organic solute transporters (OST). An essential role of bile acid transporters is evident from the pathology associated with their genetic disruption or dysregulation of their function.
Bile Acid Transporters: Structure, Function, Regulation and ...
2007年4月3日 · Enterohepatic circulation of bile acids is fundamentally composed of two major processes: secretion from the liver and absorption from the intestine. In the hepatocytes, the vectorial transport of bile acids from blood to bile is ensured by Na + taurocholate co-transporting peptide (NTCP) and organic anion transport polypeptides (OATPs).
Bile acid transporters - ScienceDirect
2009年12月1日 · In the liver, bile acids are efficiently transported across the sinusoidal membrane by the Na+ taurocholate cotransporting polypeptide with assistance by members of the organic anion transporting polypeptide family. The bile acids are then secreted in an ATP-dependent fashion across the canalicular membrane by the bile salt export pump.
Bile Acids Transporters of Enterohepatic Circulation for Targeted …
2022年5月5日 · Bile acids (BAs) are important steroidal molecules with a rapidly growing span of applications across a variety of fields such as supramolecular chemistry, pharmacy, and biomedicine. This work provides a systematic review on their transport processes within the enterohepatic circulation and related processes.
Hepatobiliary Transport: Molecular Mechanisms of Development …
1998年8月1日 · Bile acid transport. The secretion of monovalent bile acids into the canaliculus is the rate-limiting step in the overall transport of bile acids from blood to bile.
Bile acid transporters - PubMed
Following their movement with bile into the lumen of the small intestine, bile acids are almost quantitatively reclaimed in the ileum by the apical sodium-dependent bile acid transporter. The bile acids are shuttled across the enterocyte to the basolateral membrane and effluxed into the portal circulation by the recently indentified heteromeric ...
Bile acid transporters and regulatory nuclear receptors in the …
2013年1月1日 · Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation where BAs exert their multiple physiological functions including stimulation of bile flow, intestinal absorption of lipophilic nutrients, solubilization and excretion of cholesterol, as well as antimicrobial and metabolic effects.
Bile acid transporters - Journal of Lipid Research
In the liver, bile acids are efficiently transported across the sinusoidal membrane by the Na + taurocholate cotransporting polypeptide with assistance by members of the organic anion transporting polypeptide family. The bile acids are then secreted in an ATP-dependent fashion across the canalicular membrane by the bile salt export pump.
BILE ACID TRANSPORT - ScienceDirect
1999年3月1日 · Biochemical features of bile acid transport have been determined in different experimental models, such as isolated rat liver perfusion, in which bile acids are infused in the portal vein and their appearance in bile is measured; in primary hepatocytes in culture; and in bile acid transport studies using enriched sinusoidal or canalicular ...
Role of bile acids and their receptors in gastrointestinal and …
2022年2月14日 · Bile acids (BAs) can regulate their own metabolism and transport as well as other key aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors.