A B cell is activated by its first encounter with an antigen (its "cognate antigen") that binds to its receptor, resulting in cell proliferation and differentiation to generate a population of antibody-secreting plasma B cells and memory B cells.

B-cell activation is triggered by the binding of antigen to the B-cell receptor (BCR). The early molecular events triggered by BCR binding of ligand have been well-characterized both biochemically and using optical microscopy techniques to visualize B-cell activation as it happens.

Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells.

A B-Cell Receptor (BCR) is a unique receptor found on the surface of normal B cells. It consists of pairs of immunoglobulin heavy (IgH) and light (IgL) chains, which allow the BCR to recognize and bind to a variety of antigens.

The B cell receptor (BCR) covers the surface of mature B cells, and initiates cellular responses that lead to B cell activation and antibody production. Each B cell expresses a unique B cell receptor with specificity for a unique antigen.

2022年10月25日 · Researchers at Harvard Medical School and the University of Freiberg in Germany have captured the first, long-awaited snapshots at near-atomic resolution of B-cell receptors — intricate assemblages of proteins protruding from the surface of B cells that detect invaders such as viruses and bacteria and alert the cells to fight.

2022年8月18日 · To solicit T cell help, the BCR functions as an endocytic receptor that captures the antigen and delivers it to intracellular vesicles for proteolytic processing and loading onto major histocompatibility complex class II (MHC II) molecules, which are recognized by antigen-specific helper T cells.

4 天之前 · B-cell receptor (BCR) complexes are expressed on the surface of a B-cell and are critical in antigen recognition and modulating the adaptive immune response. Even though the relevance of ...

2019年7月8日 · Over the past several decades, B cell antigen receptor (BCR)-induced signaling pathways have been described in extraordinary molecular detail, mainly from studies of B cell responses to...

B cell receptor (BCR) signaling plays an important pathogenic role in chronic lymphocytic leukemia (CLL) and B cell lymphomas, based on structural restrictions of the BCR, and BCR-dependent survival and growth of the malignant B cells.