Aldosterone and Blood Pressure Regulation | Hypertension
2013年11月4日 · For >60 years, the link between aldosterone and hypertension has remained a key focus of research. The focus on this hormone and how it regulates blood pressure (BP) date back to a period of time when its putative existence, separate from that of glucocorticoids, was only speculated.
Aldosterone and the Risk of Hypertension - PMC - PubMed …
We critique recent studies that demonstrate a higher than previously believed prevalence of primary hyperaldosteronism among hypertensive patients, note current recommendations for the diagnosis of the condition, and underscore the use of aldosterone antagonists for treating resistant hypertension. Aldosterone, Mineralocorticoid Receptor, and ...
Mechanisms of Hypertension: The Expanding Role of Aldosterone
Aldosterone, the principal human mineralocorticoid, is increasingly recognized as playing a significant role in cardiovascular morbidity, and its role in hypertension has recently been reevaluated with studies that suggest that increased aldosterone biosynthesis (as defined by an elevated aldosterone to renin ratio) is a key phenotype in up to ...
Aldosterone, Inflammation, Immune System, and Hypertension
Excess aldosterone production occurring in diseases such as essential hypertension, primary aldosteronism, diabetes mellitus, and obesity contributes to increase blood pressure (BP). Over time, elevated BP, and/or aldosterone cause renal and vascular injury, which activates the innate and adaptive immune systems causing further tissue injury ...
Hyperaldosteronism - StatPearls - NCBI Bookshelf
2024年10月6日 · Hypertension in aldosteronism is primarily caused by sodium reabsorption, volume expansion, and increased peripheral vascular resistance. Symptoms are typically a result of moderate to severe hypertension or secondary to hypokalemia.
Aldosterone: What It Is, Function & Levels - Cleveland Clinic
2022年9月12日 · Aldosterone (ALD) is a hormone that helps regulate your blood pressure by managing the levels of sodium (salt) and potassium in your blood and impacting blood volume. Having too much or too little aldosterone in your body …
Adverse Effects of Aldosterone: Beyond Blood Pressure
2024年3月18日 · It is well established that overt primary aldosteronism (PA), a condition of chronic and maladaptive aldosterone production that is relatively independent of its usual regulatory pathways, is a cause of often severe or resistant hypertension.
Hyperaldosteronism: What It Is, Causes, Symptoms & Treatment
2022年9月12日 · Hyperaldosteronism is a condition in which one or both of your adrenal glands produce too much aldosterone. Aldosterone is a hormone that helps regulate your blood pressure by controlling the levels of potassium and sodium in your blood.
Clinical Management of Primary Aldosteronism: An Update
2024年7月24日 · Simplified algorithm for the systematic search of primary aldosteronism (PA) in patients with arterial hypertension. The aldosterone:renin ratio (ARR) is the most commonly used screening test. Low cutoffs, such as 20.6 ng/mIU, are used to …
Primary Hyperaldosteronism - StatPearls - NCBI Bookshelf
2023年12月5日 · Primary hyperaldosteronism (PA) is an underdiagnosed cause of hypertension. The presentation is classically known to occur in a patient with hypertension and hypokalemia. However, in reality, most patients will present without hypokalemia. The two primary causes are aldosterone-producing adenomas and bilateral adrenal hyperplasia of the zona glomerulosa. …