2023年5月24日 · By preventing immediate autophagy induction and preserving essential autophagy components, AMPK enables cells to quickly resume autophagy and restore homeostasis when energy stress subsides.

2022年11月24日 · AMPK inhibits anabolic activities that are activated due to a lack of energy or nutrients and switches off cell growth. While regulating the function of autophagy, AMPK’s role in adapting cell metabolism to energy supply is also conserved in various organisms from …

2011年1月23日 · Under glucose starvation, AMPK promotes autophagy by directly activating Ulk1 through phosphorylation of Ser 317 and Ser 777. Under nutrient sufficiency, high mTOR activity prevents Ulk1...

AMPK promotes autophagy directly by phosphorylating autophagy-related proteins in the mTORC1, ULK1, and PIK3C3/VPS34 complexes or indirectly by regulating the expression of autophagy-related genes downstream of transcription factors such as FOXO3, TFEB, and BRD4.

AMPK is a highly conserved sensor of intracellular adenosine nucleotide levels that is activated when even modest decreases in ATP production result in relative increases in AMP or ADP. In response, AMPK promotes catabolic pathways to generate …

By specifically phosphorylating autophagy-related protein complexes, AMPK promotes autophagy at multiple levels of autophagy regulation (Blagih et al., 2012). Autophagy is a lysosome/vacuole-dependent catabolic pathway in eukaryotes that is evolutionarily conserved (Lahiri et al., 2019).

2021年8月21日 · Under energy-deprived conditions, AMPK is activated triggering autophagy, whereas, in nutrient-rich conditions, the growth-promoting kinase mTORC1 is activated inhibiting autophagy. Thus, the reciprocal regulation of autophagy by AMPK and mTORC1 defines a fundamental mechanism by which cells respond to nutrient availability.