Subretinal Injection Techniques for Retinal Disease: A Review
Schematic of subretinal injection. An iatrogenic retinal detachment is produced after accessing the subretinal space (SRS), the area between the neurosensory and the retinal pigment epithelium (RPE). Subretinal injection allows direct contact of the drug with photoreceptors and RPE layers.
Subretinal Tissue Plasminogen Activator (tPA) for the Treatment …
While favorable results are achieved with intravitreal tPA and pneumatic displacement, there remain concerns about the ability of tPA to penetrate into the subretinal space. Some studies suggest that direct injection of tPA into the subretinal space can produce improved results over intravitreal tPA. 4
Management of Submacular Hemorrhage - EyeWiki
Subretinal hemorrhage is an accumulation of blood between the neurosensory retina and the retinal pigment epithelium (RPE) arising from the choroidal or retinal circulation.
The Role of Subretinal Injection in Ophthalmic Surgery: …
Subretinal injection is performed in vitreoretinal surgery with two main aims, namely, the subretinal delivery of therapeutic agents and subretinal injection of fluid to induce a controlled and localized macular detachment.
Surgical Technique for Subretinal Gene Therapy in Humans... : …
Subretinal gene therapy is effective based on available literature. The Phase III study of voretigene neparvovec-ryzl injection for RPE65-mediated IRD 1 without pre-bleb or triamcinolone visualization led to FDA approval.
Subretinal Injection Techniques for Retinal Disease: A Review
2022年8月12日 · For this, subretinal injection is becoming increasingly popular among researchers and clinicians. To date, several approaches for subretinal injection have been described in the scientific literature, all of them effective in accessing the subretinal space.
Management of Submacular Hemorrhage
2018年2月1日 · Submacular hemorrhage (SMH) is an uncommon complication of choroidal or retinal vascular abnormalities, including choroidal neovascularization (CNV), polypoidal choroidal vasculopathy (PCV), and retinal macroaneurysm. Of these, PCV is the condition most frequently associated with large SMH (reported in 20%-63% of eyes with PCV).
10 Tips for Subretinal Delivery - Retina Today
Subretinal delivery involves iatrogenic detachment of the retina inside or outside of the macula and sometimes the fovea. While the subretinal delivery technique varies slightly between trials, the common goal is to detach the retina as safely as possible, deliver the agent without causing outer retina and RPE damage, and inject enough product ...
Subretinal | definition of subretinal by Medical dictionary
Looking for online definition of subretinal in the Medical Dictionary? subretinal explanation free. What is subretinal? Meaning of subretinal medical term. What does subretinal mean?
Subretinal injection in mice to study retinal physiology and disease
2022年4月13日 · Subretinal injection (SRI) is used to access and deliver agents to the subretinal space. Clinically, it is a crucial step during vitrectomy surgery in the management of submacular hemorrhages 1...