Phosphoinositides as membrane organizers - Nature
2022年5月19日 · Here we review our current understanding of how phosphoinositides shape and direct membrane dynamics to impact on cell physiology, and provide an overview of emerging concepts in...
Understanding phosphoinositides: rare, dynamic, and essential …
PPIs ( polyphosphoinositides) are reversibly phosphorylated derivatives of the membrane phospholipid phosphatidylinositol (PI, Figure 1A). They are low-abundance lipids of the cytoplasmic leaflet of all eukaryotic cellular membranes.
Phosphoinositides: multipurpose cellular lipids with emerging …
2019年2月11日 · Phosphorylated phosphatidylinositol lipids, or phosphoinositides, critically regulate diverse cellular processes, including signalling transduction, cytoskeletal reorganisation, membrane...
Phosphoinositides: lipid regulators of membrane proteins - PMC
Phosphoinositides are a family of minority acidic phospholipids in cell membranes. Their principal role is instructional: they interact with proteins. Each cellular membrane compartment uses a characteristic species of phosphoinositide.
Frontiers | Phosphoinositides: Regulators of Nervous System …
Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have emerged as regulators of key sub-cellular processes such as membrane transport, cytoskeletal function and plasma membrane signaling in eukaryotic cells.
Phosphoinositides in cell regulation and membrane dynamics
2006年10月12日 · Phosphoinositides achieve direct signalling effects through the binding of their head groups to cytosolic proteins or cytosolic domains of membrane proteins. Thus, they can regulate the...
Understanding phosphoinositides: rare, dynamic, and essential …
2019年1月7日 · Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death.
Phosphoinositide switches in cell physiology - From molecular ...
Phosphoinositides (PIPs) are phosphorylated derivatives of phosphatidylinositol (PI), a ubiquitous phospholipid in the cytoplasmic leaflet of eukaryotic membranes that serves a plethora of functions ranging from cell signaling to membrane dynamics and host–pathogen interactions (1, …
Phosphoinositide - an overview | ScienceDirect Topics
Phosphoinositides are phospholipids within cell membranes. The general structure of the phosphoinositides comprises two fatty acid chains linked to a glycerol moiety and to a water soluble inositol head group, which can undergo differential phosphorylation.
Phosphoinositide Pathway | Cell Signaling Technology
Phosphoinositides are universal signaling entities that regulate cell activities through direct interaction with membrane proteins (e.g., ion channels, GPCRs) or through membrane recruitment of cytosolic proteins containing domains that directly bind phosphoinositides, such as pleckstrin homology (PH), FYVE, WD40 repeats, FERM, PTB, and PDZ doma...
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