Pyrantel Pamoate - an overview | ScienceDirect Topics
2015年5月7日 · Pyrantel Pamoate. In subject area: Neuroscience. Pyrantel pamoate is a compound that acts by causing neuromuscular blockade and blocking acetylcholinesterase, leading to spastic paralysis and muscle contracture in worms, allowing their expulsion from the body. AI generated definition based on: Infectious Diseases (Fourth Edition), 2017.
Pyrantel Pamoate - an overview | ScienceDirect Topics
Pyrantel pamoate is an excellent choice for eliminating nematodes if the amphibian may be orally medicated. A typical dose is 5 to 10 mg/kg PO repeated every 7 days for 28 days. A combination of pyrantel pamoate and praziquantel (Drontal) has been used, and the dosage is determined by the amount of pyrantel pamoate.
Pharmacology of Pyrantel - ScienceDirect
2016年1月1日 · Pyrantel pamoate (Strongid, Nemocid) may be used for the treatment of hookworms and roundworms in humans, pets, and other animals with effects that can vary according to parasite species and resistance status [3]. Hookworms and Trichuris species are typically less susceptible to pyrantel than Ascaris species and related roundworms [3].
In vivo efficacy of pyrantel pamoate as a post-exposure …
2022年8月1日 · Pyrantel pamoate is an FDA-approved, over-the-counter (OTC) anthelmintic that showed significant in vitro efficacy against A. cantonensis L3s in our previous studies (Jacob et al., 2021b). Pyrantel pamoate is commonly used for pinworms ( Enterobius vermicularis ) as well as for lungworms, filariae, and arthropods ( Martin and Geary, 2016 ...
Efficacy of an oral combination of moxidectin ... - ScienceDirect
2023年9月1日 · Pyrantel pamoate is a tetrahydropyrimidine nematocidal compound that has been used for over 50 years in several animal species and in humans (Bradley and Conway, 1970; Katz, 1977; Plumb, 2011). As it is poorly absorbed through the gastrointestinal mucosa, pyrantel pamoate remains in high concentration in the lumen where it kills intestinal ...
Apparent treatment failure of praziquantel and pyrantel pamoate …
2023年8月1日 · Praziquantel and pyrantel pamoate reduced anoplocephalid egg counts by 23.5 and 50.9%, respectively. • Praziquantel eliminated anoplocephalid eggs from 3 of 17 horses. • Pyrantel pamoate did not eliminate anoplocephalid eggs from any of the 14 tapeworm-positive horses. • Strongylid egg count data suggested resistance to both ivermectin ...
Safety of an oral combination of moxidectin, afoxolaner, and …
2024年6月1日 · Pyrantel pamoate is minimally absorbed through the gastro-intestinal mucosa and has been used for several decades as a gastro-intestinal nematicide compound in several animal species and in humans (Bradley and Conway, 1970; Katz, 1977; Plumb, 2011). In NexGard® PLUS, pyrantel is dosed at 5 to 10 mg/kg, in line with the usual dosages of 2.5 to ...
Anthelmintics for drug repurposing: Opportunities and challenges
2021年5月1日 · Regarding the anti-parasitic effects of pyrantel pamoate, it has been demonstrated that this drug is a potent anthelmintic drug against Strongylus worms (Yuriadi et al., 2019), in which an oral dose of the drug (20 mg/kg) caused a reduction in the eggs per gram (EPG) of feces to zero for Strongylus worms, 12 days after administration in horses.
Oxantel - an overview | ScienceDirect Topics
Oxantel is the m -oxyphenol analog of pyrantel with particular anthelmintic activity against Trichuris spp. It was discovered in the early 1970s by Pfizer and showed high activity in Trichu. muris -infected mice and Trichu. vulpis -infected dogs [21,51].
Pharmaceutical salts: A summary on doses of salt formers from the ...
2013年7月16日 · Three pamoate-salts have been FDA approved: Hydroxyzine-pamoate, Imipramine-pamoate and Pyrvinium-pamoate (discontinued). With regards to their stoichiometry the first one represents a 1:1 salt whereas the latter two are 2:1 salts. All APIs are intended for oral treatments.