2024年8月20日 · Oncogene is one of the world’s leading cancer journals. It is published weekly and covers all aspects of the structure and function of Oncogenes.

An oncogene is a gene that has the potential to cause cancer. [1] . In tumor cells, these genes are often mutated, or expressed at high levels. [2] Most normal cells undergo a preprogrammed rapid cell death (apoptosis) if critical functions are altered and then malfunction.

癌基因 （英語： oncogene）又称 致癌基因，是一类能使正常细胞转化为 癌细胞 的基因。 一般而言，癌基因是功能出现异常的原癌基因。 原癌基因 （proto-oncogene）是正常细胞就具有的基因，一般与调控细胞的生长和增殖相关，功能正常的原癌基因并不会导致癌症，突变后转化成为致癌的癌基因。 当原癌基因发生片段丢失、 点突变 、 复制 等突变后，就可能转化为癌基因 [1][2]。 原癌基因向癌基因的突变一般是获得功能的 显性 突变，一对 等位基因 中只要有一个座位上的原 …

2023年5月1日 · Oncogenes are important classes, or groups, of genetic mutations that cause cancer. They’re mutated forms of genes that control how cells grow and divide. Research shows specific oncogenes drive and support certain cancers. By targeting oncogenes, medical researchers have developed new ways to treat these cancers. What are oncogenes?

An oncogene is like a gas pedal that is stuck down, which causes the cell to divide out of control. Oncogenes can be turned on (activated) in cells in different ways. For example: Gene variants/mutations: Some people have differences in the ‘code’ of their genes that can cause an oncogene to be turned on all the time. These types of gene ...

1 天前 · An oncogene is a mutated gene that has the potential to cause cancer. Before an oncogene becomes mutated, it is called a proto-oncogene, and it plays a role in regulating normal cell division. Cancer can arise when a proto-oncogene is mutated, changing it into an oncogene and causing the cell to divide and multiply uncontrollably.

Oncogene aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research. We propagate work that challenges standard conjecture...

2024年2月21日 · Oncogenes are mutated forms of normal genes (called proto-oncogenes) that promote cell growth. Once mutated, oncogenes trigger "gain-of-function" activities, which may promote cancer development or make cancer more difficult to treat. Tumor suppressor genes normally manage cell growth and prevent tumor development.

Studies of tumor viruses revealed that specific genes (called oncogenes) are capable of inducing cell transformation, thereby providing the first insights into the molecular basis of cancer.

2024年11月26日 · OncoKB™ is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancer.