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Macrocycles are often described as molecules and ions containing a ring of twelve or more atoms. Classical examples include the crown ethers, calixarenes, porphyrins, and cyclodextrins. Macrocycles describe a large, mature area of chemistry. 展开
• Chambron, J-C.; Dietrich-Buchecker, C.; Hemmert, C.; Khemiss, A-K.; Mitchell, D.; Sauvage, J-P.; Weiss, J. (1990). "Interlacing molecular … 展开
In stereochemistry, macrocyclic stereocontrol refers to the directed outcome of a given intermolecular or intramolecular chemical reaction that is governed by the 展开
One important application are the many macrocyclic antibiotics, the macrolides, e.g. clarithromycin. Many metallocofactors are bound to macrocyclic … 展开
CC-BY-SA 许可证中的维基百科文本 Macrocycles: lessons from the distant past, recent developments, …
在pubs.rsc.org上查看更多信息While macrocycles have found use in many different areas of chemical science, it is the preorganization of binding elements in the course of a biologically relevant protein/ligand interaction that has been the topic of particularly intense efforts over the past decade. The sustained interest in macrocycles has coincided with a noti…- 作者: Andrei K. Yudin
- Publish Year: 2015
Macrocycles in Drug Discovery─Learning from the Past …
2023年4月5日 · Macrocycles are generally defined as organic molecules which contain a ring of at least 12 heavy atoms. The general interest in macrocycles across different fields of science started to grow some years before 1980 and …
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The exploration of macrocycles for drug discovery - Nature
Macrocycles have demonstrated repeated success when addressing targets that have proved to be highly challenging for standard small-molecule drug discovery, especially in modulating...
The Missing Link(er): A Roadmap to Macrocyclization in Drug …
2024年8月22日 · Macrocycles are one of nature’s preferred choices to generate large but cell-permeable bioactive molecules. Macrocyclization is increasingly prominent in medicinal …
Design, synthesis and applications of responsive macrocycles
2020年12月17日 · Macrocycles have been widely studied for their structure-specific and highly selective recognition properties. Here the authors review the design, synthesis and …
Introduction: Macrocycles | Chemical Reviews - ACS …
2019年9月11日 · The subjects covered include macrocycles as ion-pair receptors , synthesis of macrocycles using multicomponent approaches , the intriguing aspects of macrocycle/protein interactions , control over helix mimicry using …
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Macrocycles: MCR synthesis and applications in drug discovery
2016年10月7日 · Macrocycles are an emerging and largely underexploited part of chemical space where potential drugs for difficult genomic targets can be discovered. Macro-cycles can have …
Tools and rules for macrocycles | Nature Chemical …
2014年7月20日 · Recent studies advance our understanding of the way macrocycles bind protein targets and provide new strategies and tools to generate peptide-based macrocycles.
A perspective article that reviews the history, properties, and applications of macrocycles, which are cyclic compounds comprising 12 atoms or more. It covers the challenges and opportunities …
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