RNA therapeutics are a new class of medications based on ribonucleic acid (RNA). Research has been working on clinical use since the 1990s, with significant success in cancer therapy in the early 2010s. [1] . In 2020 and 2021, mRNA vaccines have been developed globally for use in combating the coronavirus disease (COVID-19 pandemic). [2] .

2022年5月21日 · Recent rapid advances in biotechnology and molecular medicine have enabled the production of almost any functional protein/peptide in the human body by introducing mRNA as a vaccine or...

2022年11月3日 · Early clinical trials of mRNA therapeutics include studies of paracrine vascular endothelial growth factor (VEGF) mRNA for heart failure and of CRISPR–Cas9 mRNA for a congenital...

2023年10月7日 · This review begins with a discussion of mRNA modifications and delivery vehicles, as well as the factors that influence administration routes. Then, we summarize the potential applications of mRNA-based drugs and discuss further key points pertaining to preclinical and clinical development of mRNA drugs targeting a wide range of diseases.

2023年6月13日 · In this Review, we present in vitro transcribed mRNA-based therapeutics for cancer treatment, including the characteristics of the various types of synthetic mRNA, the packaging systems for...

mRNA—or messenger RNA—is a molecule that contains the instructions or recipe that directs the cells to make a protein using its natural machinery. To enter cells smoothly, mRNA travels within a protective bubble called a Lipid Nanoparticle.

2023年4月26日 · Messenger RNA (mRNA) has become a key focus in the development of therapeutic agents, showing significant potential in preventing and treating a wide range of diseases. The COVID-19 pandemic in 2020 has accelerated the development of mRNA nucleic therapeutics and attracted significant investment fro …

2022年5月21日 · The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range of incurable diseases. Recent rapid advances in biotechnology and molecular medicine have enabled the production of almost any functional protein/peptide in the human body by introducing mRNA as a vaccine or the …

2023年9月1日 · The principle of antigen-encoded mRNA therapy is utilizing the in vitro transcribed mRNA to produce targeted antigens in vivo which can stimulate the host's immune response to defend against diseases. This therapy mainly involves three processes, including mRNA synthesis, intracellular processing, and immune response.

The application of messenger RNA (mRNA) technology in antigen-based immuno-oncology therapies represents a significant advancement in cancer treatment. Cancer vaccines are an effective combinatorial partner to sensitize the host immune system to the ...

2024年3月23日 · Here, we will summarise the recent advances in mRNA technology; its use in vaccines, immunotherapeutics, protein replacement therapy, and genomic editing; and its delivery to desired specific cell types and organs for development of a new generation of targeted mRNA-based therapeutics.

In vitro–transcribed mRNA (IVT mRNA) is emerging as a new class of drug that has the potential to play a role in gene therapy that once was envisioned for DNA. 1 Although first described as a therapeutic in 1992, 2 IVT mRNA's immunogenicity prevented its development for protein replacement therapies.

6 天之前 · “The costs are a major barrier for CAR T-cell therapy. If we use mRNA instead, we can take blood from a patient, decode it, identify what we have to fight against and make mRNA at a relatively low cost to inject into the patient,” he said. “If we have a good vehicle to target an organ, we can deliver the mRNA into the lymph nodes and spleen.

2024年9月14日 · Graphical overview of key mechanisms and applications of mRNA therapy. The fundamental concept of mRNA vaccines revolves around the utilization of mRNA synthesized in vitro to produce specific antigens within the body. These antigens, in turn, prompt the immune system to respond and confer protection against various diseases.

The principle of antigen-encoded mRNA therapy is utilizing the in vitro transcribed mRNA to produce targeted antigens in vivo which can stimulate the host's immune response to defend against diseases. This therapy mainly involves three processes, including mRNA synthesis, intracellular processing, and immune response.

Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution in the pharmaceutical industry because they can be used for precise and individualized therapy, and enable patients to produce therapeutic proteins in their own bodies without struggling with the comprehensive man …

2024年11月14日 · In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non-immunogenic applications. This surge in interest can be largely...

2023年9月20日 · In this review, we present an overview of different RNA‐based strategies to generate novel therapeutics, including antisense and RNAi‐based mechanisms, mRNA‐based approaches, and CRISPR‐Cas‐mediated genome editing.

2025年2月4日 · Additionally, IL2 mRNA therapy induced T-cell proliferation and activation, further augmenting the efficacy of ICB. Together, these three therapies established a positive feedback loop that enhanced the therapeutic effects of ICB. This multifunctional nanotherapeutic platform effectively reprogrammed the “cold,” suppressive immune TME ...

2025年1月23日 · Also, trials for sickle cell disease and beta-thalassemia, two genetic blood disorders, are underway. A notable advancement is the University of Pennsylvania’s Perelman School of Medicine’s mRNA gene therapy, which can correct the gene mutation that causes sickle cell in human cells without having to alter cells outside the body.