Integrin - Wikipedia
Integrin subunits span the cell membrane and have short cytoplasmic domains of 40–70 amino acids. The exception is the beta-4 subunit, which has a cytoplasmic domain of 1,088 amino acids, one of the largest of any membrane protein.
Integrins: An Overview of Structural and Functional Aspects
Integrin-engagement triggers the formation of membrane extensions that are required for cell spreading on ECM surfaces, for migration of cells into sheets of other cells, or for engulfment of particles or pathogens by phagocytic cells.
Targeting integrin pathways: mechanisms and advances in …
2023年1月2日 · Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms, including protein-protein interactions, conformational changes, and...
Integrins - Molecular Biology of the Cell - NCBI Bookshelf
Integrins are crucially important because they are the main receptor proteins that cells use to both bind to and respond to the extracellular matrix. An integrin molecule is composed of two noncovalently associated transmembrane glycoprotein subunits called α and β (Figure 19-64; see also Figure 19-12B). Because the same integrin molecule in ...
The role of integrins in inflammation and angiogenesis
2020年10月7日 · This review presents current evidence from human and animal studies on integrin structure and molecular signaling, with particular emphasis on signal transduction in infants.
Organization, dynamics and mechanoregulation of integrin
2022年9月27日 · Integrin adhesion complexes (IACs) are highly dynamic and one of their key features is their ability to transduce and respond to mechanical forces.
Integrin adhesion complexes: Current Biology - Cell Press
2021年5月24日 · Integrin-mediated cell adhesion is regulated at multiple levels. These include the regulation of integrin expression, ligand availability, heterodimer specificity and activity, and the recruitment of different intracellular proteins.
The gripping story of integrins - Cell Press
2022年10月13日 · We now know there are 18 α and 8 β integrin subunits that create 24 distinct α-β integrin pairs. Boosted by combinatorial expression of these distinct heterodimers and their partially overlapping ligand specificities, integrins encode a vast repertoire of intelligent material properties in ways which we continue to learn about.
Integrin signalling and function in immune cells - PMC
Mutations in integrins or the major effectors of integrin signalling pathways cause defective organ development, immunodeficiency, cancer or autoimmune disease. Understanding of the signalling events that drive integrin activation and signalling is therefore crucial to uncover the molecular mechanisms of these diseases.
Integrins in Health and Disease | New England Journal of Medicine
2022年9月28日 · Dr. Hynes coined the term “integrin” for these wonderfully complicated molecules that “integrate” the extracellular matrix with the intracellular environment (the cytoskeleton, in particular).