Cell signaling in response to an array of diverse stress stimuli converges on the phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2).

2024年12月24日 · EIF2A (Eukaryotic Translation Initiation Factor 2A) is a Protein Coding gene. Among its related pathways are Host-pathogen interaction of human corona viruses - ER stress and Nanog in Mammalian ESC Pluripotency .

Key themes in the review will be the mechanisms regulating eIF2α kinases, the role that upstream open reading frames (uORFs) play in translational control, and the impact that altered P-eIF2α levels by gene mutations or small molecule inhibitors can have on health and disease.

2025年2月9日 · Data show that high level of pancreatic endoplasmic reticulum kinase (PERK) and eukaryotic translation initiation factor 2A (p-eIF2 [alpha]) expression in patients with pancreatic ductal adenocarcinoma (PDAC) correlated with poor survival.

Translation initiation factor 2α (eIF2α) kinase phosphorylates Serine51 (Ser51) of eIF2α and downregulates cellular protein synthesis. Structural information on eIF2α reveals that Ser51 is located within a flexible loop, referred to as the Ser51 loop.

2020年6月8日 · In synthesis, it appears that eIF2α phosphorylation is a central event for the stimulation of autophagy. The so-called integrated stress response 1, 2, 3 is characterized by the phosphorylation...

2025年1月17日 · We systematically test here by ribosome profiling and luciferase reporter assays the role of eIF2A in translation initiation, including translation of upstream ORFs that are either initiated with a canonical AUG or near-cognate codons.

The stress-resistant initiator tRNA carrier, eIF2A, was recently uncovered and shown to load Met-tRNA iMet on the 40S ribosomal subunit associated with a stress-resistant mRNA under stress conditions.

2020年3月17日 · Eukaryotic initiation factor 2A (eIF2A) is a single chain 65 kDa protein that was initially believed to serve as the functional homologue of prokaryotic IF2, since eIF2A and IF2 catalyze biochemically similar reactions, i.e., they stimulate initiator Met-tRNAi binding to the small ribosomal subunit.

This gene should not be confused with EIF2S1, frequently called eIF2-alpha in the literature, and with which it shares the alias EIF2A. EIF2S1 is the alpha subunit of the eIF2 translation initiation complex.