Dihydroxylation is the process by which an alkene is converted into a vicinal diol. Although there are many routes to accomplish this oxidation , the most common and direct processes use a high-oxidation-state transition metal (typically osmium or manganese).

2019年2月13日 · Alkenes can be dihydroxylated by two different stereochemical pathways: anti-dihydroxylation or syn-dihydroxylation. The opening of epoxides follows the anti-dihydroxylation mechanism, while potassium permanganate or osmium tetroxide produce the …

Dihydroxylation is an oxidation process when an alkene is converted into a vicinal diol, also known as 1,2-diols or glycols. The most frequent and direct process of dihydroxylation is using a transition metal in a high oxidation state, typically osmium (VIII) or manganese (VII).

2011年7月1日 · Osmium tetroxide (OsO 4) is a useful reagent for the dihydroxylation of alkenes; The products of these reactions are 1,2-diols (“vicinal” diols), where the two C-O bonds are formed on the same face of the alkene via a concerted mechanism. Dihydroxylation of alkenes with OsO 4 is functionally equivalent to dihydroxylation with cold, basic ...

Antitumor drugs have been formed by using dihydroxylation. This method has been applied to the enantioselective synthesis of ovalicin, which is a class of fungal-derived products called antiangiogenesis agents. These antitumor products can cut off the blood supply to solid tumors.

The dihydroxylation of an alkene occurs by adding one hydroxyl group to each of the two alkene carbon atoms. From: Organic Chemistry (Second Edition), 2018

Dihydroxylation is the process by which an alkene is converted into a vicinal diol. Vicinal diols are a type of organic compounds containing hydroxyl groups in adjacent carbon atoms. These compounds are called glycols.