Beta-lactamase - Wikipedia
Beta-lactamases (β-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, …
Overview of Beta-Lactams - Overview of Beta-Lactams - The …
Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. Some beta-lactamases are encoded on …
β-Lactamases: Sequence, Structure, Function, and Inhibition
β-Lactams were the first class of antibiotics to be discovered and the second to be introduced into the clinic in the 1940s [1]. They inhibit bacterial transpeptidases (also known as penicillin …
Beta-Lactam Antibiotics - StatPearls - NCBI Bookshelf
2023年6月4日 · Beta-lactam antibiotics are one of the most commonly prescribed drug classes with numerous clinical indications. Their advent starting from the 30s of the twentieth century …
ESBL: Transmission, Treatments, and More - Healthline
2017年4月14日 · Extended-spectrum beta-lactamases (ESBL) are a type of enzyme or chemical produced by some bacteria. ESBL enzymes make some antibiotics ineffective in treating …
β-Lactams and β-Lactamase Inhibitors: An Overview - PMC
β-Lactam antibiotics are bactericidal agents that interrupt bacterial cell-wall formation as a result of covalent binding to essential penicillin-binding proteins (PBPs), enzymes that are involved in …
Beta-Lactamase - an overview | ScienceDirect Topics
Beta-lactamases are genetically and structurally closely related to penicillin-binding proteins. Their production by bacteria is a major mechanism of resistance to the action of beta-lactam …
Extended-spectrum beta-lactamases - UpToDate
2024年3月8日 · Extended-spectrum beta-lactamases (ESBLs) are enzymes that confer resistance to most beta-lactam antibiotics, including penicillins, cephalosporins, and the monobactam …
β-Lactamases: A Focus on Current Challenges - PMC - PubMed …
β-Lactamases, the enzymes that hydrolyze β-lactam antibiotics, remain the greatest threat to the usage of these agents. In this review, the mechanism of hydrolysis is discussed for both those …
Beta-lactam antibiotics: Mechanisms of action and resistance and ...
2023年11月15日 · Beta-lactam antibiotics are among the most commonly prescribed drugs, grouped together based upon a shared structural feature, the beta-lactam ring. Beta-lactam …