Thymocyte - Wikipedia
A thymocyte is an immune cell present in the thymus, before it undergoes transformation into a T cell. [1] Thymocytes are produced as stem cells in the bone marrow and reach the thymus via the blood .
A guide to thymic selection of T cells - Nature
2023年7月18日 · This Review summarizes how the processes of thymic selection together ensure that the T cell repertoire is fully functional and safe. In the thymus, T cell receptor signal strength is...
Key Factors for Thymic Function and Development - PMC
Thymocyte differentiation is regulated by direct contact with the stromal-epithelial microenvironment and responds to various cytokines produced by thymic stromal and lymphoid cells. IL-7, produced by TECs, is the key regulator of T cell maturation, differentiation, and survival in the early stages of their generation ( 37 , 159 ).
Single-cell multiomic analysis of thymocyte development ... - Nature
2023年8月14日 · The ultimate fate of a thymocyte is determined by the specificity of its T cell receptor (TCR) for major histocompatibility complex (MHC) molecules during positive selection in the thymus, with...
Thymic function in the regulation of T cells, and molecular …
2017年9月19日 · The principal roles of thymic cytokines are in constitutive processes, including thymocyte migration and development, and the mediation of cell populations, but not inducible ones, such as immune response/tolerance or inflammation, as in the periphery.
The Metabolic Landscape of Thymic T Cell Development
2021年7月28日 · This report uses transcriptomics and extracellular flux analyses to metabolically profile human and murine thymocytes ranging from early DN to mature SP stages. We also compare the metabolic profiles of primary thymic populations to those of in vitro ATO-derived populations from the DN to DP stages.
METTL3 governs thymocyte development and thymic involution …
4 天之前 · Loss of METTL3 leads to increased ferroptosis in DP cells. Cell death is the critical event that occurs during thymocyte development and can be induced by stress and aging 7, 54. Next, we took ...
Thymocyte - an overview | ScienceDirect Topics
Thymomas are rare tumors that can form at any age. However, most occur in middle-aged adults. Men and women appear to be equally affected by thymomas. The usual age at diagnosis is 30 to 40 years, though they have occurred in every age group, including children, though this is …
Thymus: Anatomy, histology and function - Kenhub
2017年6月19日 · The thymus is a primary lymphoid organ located in the mediastinum. It consists of two lobes connected by an isthmus. Histologically, the thymus is divided into lobules, each one consisting of a central medulla and a peripheral cortex. The thymus is an essential component of our immune systems.
Thymocyte - an overview | ScienceDirect Topics
Thymocyte development is a multistep complex process and based on the surface expression of CD4 and CD8 molecules it is divided into three distinct stages. The early thymocytes are CD4 − CD8 − (double negative or DN) and are subdivided into DN1 (CD44 + 25 − ), DN2 (CD44 + 25 + ), DN3 (CD44 − 25 + ), and DN4 (CD44 − 25 − ) subsets.