Synapse formation: from cellular and molecular mechanisms to ...
2019年4月5日 · Thus, synapse formation is not restricted to neurodevelopment; it is a process that remains active throughout life. As the brain ages, either the lack of neuronal activity or cell death render synapses dysfunctional, thus giving rise to neurodegenerative disorders. This review seeks to highlight salient steps that are involved in a neuron’s ...
Towards an Understanding of Synapse Formation - Cell Press
Synapses are intercellular junctions specialized for fast, point-to-point information transfer from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal secretes neurotransmitters via a canonical release machinery, while a postsynaptic specialization senses neurotransmitters via diverse receptors.
Molecular mechanisms of synaptogenesis - PMC
Synapse formation involves the interactions between neurons. As a result, neuron differentiation, migration, axon guidance, and dendrite morphogenesis can all influence the outcomes of synaptogenesis (Batool et al., 2019).
Synapse Formation, Survival, and Elimination (Section 1, Chapter …
Synapse formation is a complex and gradual process. Specific molecules from neurons and muscles play important roles in synapse formation and in regeneration (e.g., agrin). Finally, synapse elimination and rearrangement result in the fine tuning of neuronal circuitry and synapse strengthening in the nervous system.
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Physiology, Synapse - StatPearls - NCBI Bookshelf
2023年3月27日 · A synapse is made up of a presynaptic and postsynaptic terminal. The presynaptic terminal is at the end of an axon and is the place where the electrical signal (the action potential) is converted into a chemical signal (neurotransmitter release).
The origin and evolution of synapses - Nature
2009年9月9日 · The phylogeny of the molecular components of the synapse provides a new model for studying synapse diversity and complexity, and their implications for brain evolution.
Synapse | Anatomy, Function & Types | Britannica
2024年10月5日 · Synapse, the site of transmission of electric nerve impulses between two nerve cells (neurons) or between a neuron and a gland or muscle cell (effector). A synaptic connection between a neuron and a muscle cell is called a neuromuscular junction.
Chapter 48: Formation and Elimination of Synapses - McGraw …
4 天之前 · Three key processes drive synapse formation. First, axons make choices among many potential postsynaptic partners. By forming synaptic connections only on particular target cells, neurons assemble functional circuits that can process information.
Phase separation at the synapse | Nature Neuroscience
2020年2月3日 · This study provides an important piece of evidence supporting the concept that phase-separation-mediated PSD assembly formation and regulation are linked with physiological functions of...
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