Arginine vasopressin (AVP) neurons in the hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN) are involved in important physiological behaviors, such as controling osmotic stability and thermoregulation. However, the presynaptic input patterns governing AVP neurons have remained …

2024年11月27日 · We found that SFO neurons were activated after LPS treatment and that the manipulation of SFO neurons bidirectionally modulated LPS-induced anxiety-like behaviors in mice. Specifically, the activation of SFO neurons mitigated LPS-induced anxiety-like behaviors in mice but did not affect sickness behaviors.

2023年8月2日 · Here, we demonstrate that acute exposure to light impairs social recognition memory (SRM) in mice. Unlike sound and touch stimuli, light inhibits oxytocin neurons in the supraoptic nucleus (SON) via M1 SON‐projecting intrinsically photosensitive retinal ganglion cells (ipRGCs) and GABAergic neurons in the perinuclear zone of the SON (pSON).

2024年12月13日 · Oxytocin (OT), a nonapeptide hormone produced by OT neurons in the paraventricular (PVH) and supraoptic (SO) nuclei of the hypothalamus, plays an important role in facilitating uterine contractions during parturition, triggering milk ejection during lactation, and promoting maternal care toward infants (1–3).

2021年5月14日 · Using novel brain clearing techniques and 3D imaging, we have reconstructed the specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain with unprecedented...

2008年1月1日 · In this study, we examined the electrical properties of MNCs from the mouse SON. Extracellular recordings from neurons in superfused explants revealed modes of basal and osmotically modulated firing very similar to those observed previously in rats.

2023年3月17日 · The hormone oxytocin, secreted from oxytocin neurons in the paraventricular (PVH) and supraoptic (SO) hypothalamic nuclei, promotes parturition, milk ejection, and maternal caregiving behaviors. Previous experiments with whole-body oxytocin knockout mice showed that milk ejection was the unequivocal …

Osmotic control of arginine vasopressin (AVP) and oxytocin (OXT) release from magnocellular neurosecretory cells (MNCs) of the supraoptic (SON) and paraventricular (PVN) nuclei is essential for body fluid homeostasis. The electrical activity of MNCs, which is regulated by intrinsic and extrinsic osm …

2015年2月1日 · In mice expressing choline acetyltransferase (ChAT)-eGFP, large, brightly fluorescent and small, dimly fluorescent ChAT-eGFP neurons were present in the PNZ. The small ChAT-eGFP and GAD65-eGFP neurons exhibited a low-threshold depolarizing potential consistent with a low-threshold spike, with little transient outward rectification.

2020年2月29日 · 9.4.2.1.4 Supraoptic Nucleus (SON) [Nucleus supraopticus] The SON is located laterally of the optic tract (not above = supra; see Fig. 9.5). Like the PVN the SON synthesizes vasopressin and oxytocin.