Hepatitis A virus (HAV) is a positive-strand RNA virus classified in the genus Hepatovirus of the family Picornaviridae. It is an ancient virus with a long evolutionary history and multiple features of its capsid structure, genome organization, and replication cycle that distinguish it from other mammalian picornaviruses.

HAV is a nonenveloped, unusual hepatotropic picornavirus with a 7500 nucleotide positive-strand RNA genome [24–28]. The 5′ ends of the RNA are physically attached to a viral genome-linked protein (VPg) or 3B and also lack a normal cap configuration and a brief untranslated section at the 3′ ends of the genome, which ends in a poly (A) tail.

The structure of the capsid can help us to understand some aspects of this process: how capsid assembly is directed and controlled, how the genome is encapsidated, how interactions with the host cell are coordinated, how the capsid disassembles to facilitate genome replication and how the capsid organization responds to and evades the antiviral ...

2018年12月3日 · HAV proteins are produced by cap-independent translation of a single, long open reading frame under direction of an inefficient, upstream internal ribosome entry site (IRES). Genome replication occurs slowly and is noncytopathic, with transcription likely primed by a uridylated protein primer as in other picornaviruses.

The RNA genome of human hepatitis A virus (HAV) was molecularly cloned. Recombinant DNA clones representing the entire HAV RNA were used to determine the primary structure of the viral genome. The length of the viral genome is 7478 nucleotides. An open reading frame starting at nucleotide 734 and te …

2013年9月18日 · Recently published data on the following features of hepatitis A virus (HAV) are reviewed: structure-functional genome features, genotyping, clinical findings, and current means of diagnostics. The growing need to study the genetic diversity of HAV isolates and the search for its possible new antigenic variants are underlined.

Hepatitis A virus (HAV) is a positive-strand RNA virus classified in the genus Hepatovirus of the family Picornaviridae. It is an ancient virus with a long evolutionary history and multiple features of its capsid structure, genome organization, and replication cycle that distinguish it from other mammalian picornaviruses.

1987年8月1日 · Hepatitis A virus (HAV) is an important human pathogen causing hepatitis, with high incidence in developed as well as in developing countries. No vaccines are available. In order to determine the primary structure of the HAV genome, we have prepared cDNAs from viral RNA and cloned these into plasmid pBR322.

HAV genome is divided into a 5' non-coding region (5'NCR), a giant open reading frame, and a non-coding region (3'NCR). The coding region is subdivided into regions P1, P2 and P3.

[Structure and function of HAV genome (RNA)] [Structure and function of HAV genome (RNA)] Nihon Rinsho. 2004 Aug;62 Suppl 8:428-32. [Article in Japanese] Author Takashi Shimoike 1 Affiliation 1 Department of Virology II, National Institute of Infectious Diseases. PMID: 15453360 No abstract available ...