Sirtuin activators and inhibitors - PMC
We review here those compounds known to activate or inhibit sirtuins, discussing the data that support the use of sirtuin-based therapies. Almost all sirtuin activators have been described …
Sirtuin activators and inhibitors: Promises, achievements, and ...
The human Sirtuin isoforms, SIRT1-7, are considered attractive therapeutic targets for aging-related diseases, such as type 2 diabetes, inflammatory diseases and neurodegenerative …
Current Trends in Sirtuin Activator and Inhibitor Development
2024年3月6日 · Instead of being comprehensive, this review discusses the well-characterized sirtuin activators and inhibitors available to date, particularly those with demonstrated …
The sirtuin family in health and disease | Signal Transduction and ...
2022年12月29日 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are …
Natural polyphenols as sirtuin 6 modulators | Scientific Reports
2018年3月7日 · Here we show, that flavonoids can alter SIRT6 activity in a structure dependent manner. Catechin derivatives with galloyl moiety displayed significant inhibition potency …
Sirtuin activators and inhibitors: Promises, achievements, and ...
2018年8月1日 · We review the status of Sirtuin-targeted drug discovery and development. Potent and selective pharmacological Sirt1 activators and inhibitors are available, and initial clinical …
Sirtuin activators and inhibitors - PubMed
Sirtuins 1-7 (SIRT1-7) belong to the third class of deacetylase enzymes, which are dependent on NAD(+) for activity. Sirtuins activity is linked to gene repression, metabolic control, apoptosis …
SIRT1 Activation by Natural Phytochemicals: An Overview
2020年8月6日 · Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD + as a cofactor. Sirtuins are reported to modulate numerous activities by controlling …
Slowing ageing by design: the rise of NAD+ and sirtuin-activating ...
2016年8月24日 · Sirtuins are nicotinamide adenine dinucleotide (NAD +)-dependent lysine deacylases that promote longevity and healthy ageing. Sirtuin-activating compounds (STACs) …
Current Trends in Sirtuin Activator and Inhibitor Development
2024年3月6日 · Instead of being comprehensive, this review discusses the well-characterized sirtuin activators and inhibitors available to date, particularly those with demonstrated …