A senolytic (from the words senescence and -lytic, "destroying") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent …

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis‐driven …

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven …

2024年2月6日 · In this review, we present the senolytic drugs as a promising way to treat age-related diseases but also their limitations during clinical development. Recently, several new …

2024年11月21日 · Today, science is closer than it has ever been to unlocking the secrets of aging—thanks, potentially, to an emerging class of drugs called senolytics. Senescent cells, …

2022年8月11日 · In line with this, the discovery of small-molecule senolytic drugs that selectively clear senescent cells has led to promising strategies for preventing or treating multiple …

2022年10月4日 · A recent paper had a list of the most prominent possible senolytic drugs: Dasatinib, Quercetin, Fisetin, 17-DMAG, Navitoclax, Catechins. This list fits with the top …

Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. …

Senolytics are a category of drugs that reduce the impact of cellular senescence, an effect associated with a range of chronic and age‐related diseases. This review discusses current …

Senolytic drugs can eliminate p16-positive macrophages 85 and senescent vascular cells, exerting a dual approach to reverse vascular remodelling.