Cowden syndrome - DermNet
2016年7月13日 · Cowden syndrome is a rare, autosomal dominant, inherited condition characterised by hamartomas in various organs, including breast, thyroid, uterus, brain, and mucocutaneous tissues with increased risk of malignancies. It is also known as ‘Cowden disease’ or ‘multiple hamartoma syndrome’. Cowden disease is one of a spectrum of disorders ...
Dermatofibroma (histiocytoma)
A dermatofibroma can occur anywhere on the skin. Dermatofibroma size varies from 0.5–1.5 cm diameter; most lesions are 7–10 mm diameter. A dermatofibroma is tethered to the skin surface and mobile over subcutaneous tissue. The overlying skin dimples on pinching the lesion – the dimple or pinch sign. Colour may be pink to light brown in ...
Angiofibroma: Types, Appearances and Causes — DermNet
Angiofibromas are caused by a local overgrowth of collagen, fibroblasts, and blood vessels. In tuberous sclerosis, mutations are present in tuberous sclerosis complex 1 (TSC1), which encodes the protein hamartin, and tuberous sclerosis complex 2 (TSC2) which encodes the protein tuberin. Birt-Hogg-Dubé syndrome is due to a mutated FLCN gene ...
Tuberous sclerosis - DermNet
2018年5月23日 · Tuberous sclerosis or tuberous sclerosis complex (TSC) is a genetic disorder that is characterised by hamartomas in many organs, but particularly the skin, brain, eye, kidney and heart. Hamartomas are non-cancerous malformations composed of an overgrowth of the cells and tissues that normally occur in the affected area and include naevi ...
Oral irritated fibroma - DermNet
An oral fibroma presents as a firm smooth papule in the mouth. It is usually the same colour as the rest of the mouth lining but is sometimes paler or, if it has bled, may look a dark colour. The surface may be ulcerated due to trauma, or become rough and scaly. It is usually dome-shaped but may be on a short stalk like a polyp (pedunculated).
Tuberous sclerosis images - DermNet
Created 2011. > Go to the image library. Ash leaf marks in tuberous sclerosis. Ash leaf marks in tuberous sclerosis. Ash leaf marks in tuberous sclerosis. Ash leaf marks in tuberous sclerosis. Periungual fibroma in tuberous sclerosis. Periungual fibroma in tuberous sclerosis. Periungual fibroma in tuberous sclerosis.
Dermatofibroma (fibrous histiocytoma) pathology
Introduction. Dermatofibroma is a common benign tumour also known as fibrous histiocytoma. There is debate as to whether dermatofibroma has a reactive or neoplastic origin. The clinical lesion is a firm tan-brown nodule most commonly found on the legs. A …
Dermatomyofibroma pathology
Histology of dermatomyofibroma. Sections show a subtle, ill-defined, plaque-like dermal proliferation (figure 1). The cells are uniform, slender, spindle-shaped and bland. The cells contain evenly distributed chromatin or vesicular with small nucleoli and indentations is in keeping with a myofibroblastic line of differentiation.
Elastofibroma pathology - DermNet
In elastofibroma, the histopathology shows dense accumulation of eosinophilic tissue irregularly interdigitated into adipose tissue (figure 1). A higher power examination shows collagen bundles that alternate with large, thick eosinophilic elastic fibres (figures 2–4). Figure 1. Figure 2. Figure 3.
Fibrofolliculoma / trichodiscoma pathology - DermNet
Histology of fibrofolliculoma / trichodiscoma. Sections through fibrofolliculoma show a proliferation of follicular epithelium surrounded by a perifollicular fibrous sheath (figure 1–3). The epithelial strands are composed of thin cords of epithelial cells. The stroma surrounding the epithelium may be densely fibrous and sclerotic or rather ...