2024年12月25日 · STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Hyper-Ige Syndrome 1, Autosomal …

Signal transducer and activator of transcription (STAT) proteins represent novel therapeutic targets for the treatment of cancer. In particular, STAT-3 serves critical roles in several cellular …

Stat3 was first described as a DNA-binding activity from IL-6–stimulated hepatocytes, capable of selectively interacting with an enhancer element in the promoter of acute-phase genes, known …

Signal transducer and activator of transcription (STAT) 3 is one of the most complex regulators of transcription. Constitutive activation of STAT3 has been reported in many types of tumors and …

2018年12月21日 · Here, we review the tumour-modulating activities of STAT3 in light of its role as a signalling node integrating inflammatory responses during wound healing.

STAT3 is a transcription fac-tor, a type of protein that regulates when other genes are turned on. Once activated, STAT3 moves into the nucleus of the cell and binds to specific areas of DNA. …

STAT3 gene mutations are found in approximately one-third of cases of a blood cancer called large granular lymphocytic leukemia (LGL), which is characterized by the accumulation of …

STAT3 is the key regulator of cell proliferation, survival and apoptosis and is constitutively activated in most human cancers, indicating that it can be an important potential therapeutic …

2015年12月3日 · STAT3 is both a transcription activator and an oncogene that is tightly regulated under normal physiological conditions. However, abundant evidence indicates that STAT3 is …

STAT3 is a transcription factor and intracellular signalling protein. It is activated by a variety of cytokines, growth factors and intracellular kinases. In cancer, STAT3 dysregulation leads to …