A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules.

Protein kinases are important enzymes, involved in the regulation of various cellular processes. Phosphorylation and dephosphorylation provide a rapid and dynamic regulatory mechanism that controls the biological functions of most proteins and act as a molecular switch for diverse regulatory events in signaling pathways that drive cell division ...

2022年3月3日 · Protein kinases are the enzymes responsible for protein phosphorylation. Click here to know more about their types, regulation mechanisms, and functions.

Protein kinases constitute a large protein family of important regulators in all eukaryotic cells. All of the protein kinases have a similar bilobal fold, and their key structural features have been well studied.

This review focus on ‘the 10 things you should know about protein kinases and their inhibitors', including a short introduction on the history of protein kinases and their inhibitors and ending with a perspective on kinase drug discovery.

Protein kinases act on proteins, by phosphorylating them on their serine, threonine, tyrosine, or histidine residues. Phosphorylation can modify the function of a protein in many ways.

Protein kinases (PTKs) are enzymes that regulate the biological activity of proteins by phosphorylation of specific amino acids with ATP as the source of phosphate, thereby inducing a conformational change from an inactive to an active form of the protein.

Protein kinases and phosphatases are regulated by protein-protein interactions, binding of ligands, and reversible or irreversible covalent modifications such as phosphorylation and limited proteolysis.

Kinase, an enzyme that adds phosphate groups to other molecules. A large number of kinases exist, the human genome alone containing hundreds of kinase-encoding genes. Included among kinase targets for phosphorylation are proteins, lipids, and nucleic acids. Learn more about kinase targets and kinase activity.

2023年12月1日 · Kinases are proteins that are responsible for catalyzing the transfer of phosphate groups from high-energy donor molecules to other biomolecules, including a number of proteins. This transfer is necessary for many cellular processes.