Placebo-controlled study - Wikipedia
Placebo-controlled studies are a way of testing a medical therapy in which, in addition to a group of subjects that receives the treatment to be evaluated, a separate control group receives a sham "placebo" treatment which is specifically designed to have no real effect.
Placebo in clinical trials - PMC - PubMed Central (PMC)
The placebo-controlled trial “is widely regarded as the gold standard for testing the efficacy of new treatments.” Interest in placebo effects began only with the widespread adoption of the placebo-controlled clinical trials after World War II.
A Placebo-Controlled Trial of Percutaneous Coronary …
2023年11月11日 · A double-blind randomised placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina without antianginal medications: design and rationale of the ORBITA-2...
Placebo-controlled trials: good science or medical neglect?
Using a recent example of a clinical trial of a new drug for treating rheumatoid arthritis, we argue that research participants who have burdensome, progressive disease should not be exposed to the risks of placebo-controlled trials.
Double-Blind, Placebo-Controlled Clinical Trial Basics - Verywell …
2024年9月21日 · Understand how a double-blind, placebo-controlled clinical trial works and why it's an important aspect of medical studies.
What Is Controlled for in Placebo-Controlled Trials?
Randomized, double-blind, placebo-controlled clinical trials are the gold standard for determining the efficacy of an intervention. Many treatments have shown tremendous promise based on case studies and uncontrolled clinical studies, only to be found ineffective in the context of a carefully conducted placebo-controlled trial.
Placebo use in vaccine trials: Recommendations of a WHO expert …
This paper specifies four situations in which placebo use may be acceptable, provided that the study question cannot be answered in an active-controlled trial design; the risks of delaying or foregoing an efficacious vaccine are mitigated; the risks of using a placebo control are justified by the social and public health value of the research ...
Placebo Effect - StatPearls - NCBI Bookshelf
2023年11月13日 · Placebo interventions primarily serve as control treatments in experimental studies, enabling researchers to determine the specific effects of a particular treatment. Clinical investigators use randomized, double-blind, placebo-controlled trials as a gold standard to validate treatments. [8]
Placebo-Controlled Trials in Surgery - PMC - National Center for ...
2016年4月29日 · In summary, this review shows that properly conducted placebo-controlled trials can be feasible and are valid methodological instruments for the evaluation of efficacy of surgical interventions. Placebo controlled trials have a scientific value, and are mostly published in high-impact journals.
The role of placebo control in clinical trials for ... - Nature
2023年9月14日 · Platform multi-arm multi-stage (MAMS) randomized phase 3 trial designs offer demonstrable advantages, because they simultaneously enable the following: definitive evaluation of multiple treatment...