Phosphoinositide Pathway | Cell Signaling Technology
Learn how phosphatidylinositol and its phosphorylated derivatives (phosphoinositides) regulate cell activities through interaction with membrane proteins. Explore the pathway's role in Akt signaling, endocytosis, cytoskeletal changes, and more.
Phosphoinositides as membrane organizers | Nature Reviews …
2022年5月19日 · Here we review our current understanding of how phosphoinositides shape and direct membrane dynamics to impact on cell physiology, and provide an overview of emerging concepts in...
The phosphoinositide 3-kinase pathway - PubMed
2002年5月31日 · The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted.
A phosphoinositide signalling pathway mediates rapid lysosomal …
2022年9月7日 · Here, using an unbiased proteomic approach, we show that LMP stimulates a phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway for rapid lysosomal repair.
Understanding phosphoinositides: rare, dynamic, and essential …
PI(4,5)P 2 can be down-regulated at the PM via two main pathways; (1) receptor-mediated hydrolysis by various subtypes of phospholipase C (PLC), and (2) dephosphorylation by members of the PI(4,5)P 2-5-phosphatase family (SYNJ1, SYNJ2, OCRL, INPP5B, INPP5E, INPP5J, INPP5K: see Figure 1C).
Phosphoinositides: Regulators of Nervous System Function in …
2019年8月23日 · In this review we evaluate existing evidence for the involvement of phosphoinositide signaling in human nervous system diseases and discuss ways of enhancing our understanding of the role of this pathway in the human nervous system’s function in …
Phosphoinositides: multipurpose cellular lipids with emerging …
2019年2月11日 · Phosphoinositides were initially characterised as second messengers for major signalling pathways. Phosphoinositides were later found to act as docking lipids to recruit and modulate actin...
Phosphoinositide switches in cell physiology - From molecular ...
This article reviews the molecular mechanisms and biological functions of phosphoinositides, a class of phosphorylated phospholipids that act as molecular switches in various cellular processes. It also discusses the role of phosphoinositide dysregulation in human disease and the future perspectives of phosphoinositide research.
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
The spectacular progress in the 1980s in defining the pathways by which G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) activated phospholipase C (PLC) enzymes had a major impact on many scientists who showed interest in …
Phosphoinositides, Major Actors in Membrane Trafficking and …
2017年3月15日 · The link between PtdIns(3,4)P 2 and the PI3K/Akt signaling pathway suggests that this PPIn could be involved in numerous biological processes, such as controlling the cell cycle, cell survival, angiogenesis or glucose metabolism.