PITX2 - Wikipedia
Paired-like homeodomain transcription factor 2 also known as pituitary homeobox 2 is a protein that in humans is encoded by the PITX2 gene. [5][6][7] This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins.
PITX2 Gene - GeneCards | PITX2 Protein | PITX2 Antibody
2024年10月2日 · PITX2 (Paired Like Homeodomain 2) is a Protein Coding gene. Diseases associated with PITX2 include Ring Dermoid Of Cornea and Anterior Segment Dysgenesis 4. Among its related pathways are Gene expression (Transcription) and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.
PITX2 gene - MedlinePlus
The PITX2 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and regulates the activity of other genes. Learn about this gene and related health conditions.
Pitx genes in development and disease | Cellular and ... - Springer
2021年4月12日 · Pitx2 is essential for the development of the oral cavity and abdominal wall while regulates the formation and symmetry of other organs including pituitary, heart, gut, lung among others by controlling growth control genes upon activation of the Wnt/ß-catenin signaling pathway.
PITX2 deficiency and associated human disease: insights from the ...
2018年3月1日 · Affected homozygous zebrafish demonstrated congenital defects consistent with the range of PITX2- associated human phenotypes: abnormal development of the cornea, iris and iridocorneal angle; corneal dermoids; and craniofacial dysmorphism.
PAIRED-LIKE HOMEODOMAIN TRANSCRIPTION FACTOR 2; PITX2 …
PITX2 belongs to the bicoid class of homeodomain transcription factors, which play essential roles in embryonic development. Various PITX2 isoforms are involved in a wide variety of developmental programs, including left-right signaling (summary by Cox et al., 2002).
Novel forms of Paired-like homeodomain transcription factor 2 (PITX2 …
2008年3月28日 · We have identified and characterized two novel isoforms of PITX2, generated by alternative translation initiation (PITX2Cβ) and alternative mRNA splicing (PITX2B2).
PITX2 (Pituitary Homeobox Gene 2) - SpringerLink
2017年1月1日 · PITX2 is abnormally expressed in hypertrophic cardiomyopathy and heart failure patients (Torrado et al. 2014), and PITX2 function is indispensable to provide normal regenerative potential to the myocardium in neonatal stages by controlling redox homeostasis (Tao et al. 2016).
Frontiers | Pitx2 Differentially Regulates the Distinct Phases of ...
In this study we have generated two conditional Pitx2 mutant mice to differentially inactivate Pitx2 at the onset of myogenic specification (Pax3 Cre/Wt /Pitx2 −/− mutant mice) and/or after the acquisition of myogenic fate (Myf5 Cre/Wt /Pitx2 −/− mutant mice).
A cellular atlas of Pitx2- dependent cardiac development
2019年6月14日 · The Pitx2 gene encodes a homeobox transcription factor that is required for mammalian development. Disruption of PITX2 expression in humans causes congenital heart diseases and is associated with atrial fibrillation; however, the cellular and molecular processes dictated by Pitx2 during cardiac ontogeny remain