Poly (amidoamine), or PAMAM, is a class of dendrimer which is made of repetitively branched subunits of amide and amine functionality.

Poly (amidoamine) (PAMAM) dendrimers are hyper-branched polymers with unparalleled molecular uniformity, narrow molecular weight distribution, defined size and shape characteristics and a multi-functional terminal surface. These nanoscale polymers consist of:

PAMAM (polyamidoamine) was introduced in 1985, by Donald A. Tomalia, as a new class of polymers, named ‘starburst polymers’. This important contribution of Professor Tomalia opened a new research field involving nanotechnological approaches.

2016年2月1日 · Poly (amidoamine) (PAMAM) dendrimers have received attention due to their large surface areas with high concentration of functional end groups to bind biological material. They are monodisperse and hyper-branched polymers which include active functional groups outside its surface.

2022年12月1日 · PAMAM dendrimers are among the most widely explored family of dendrimers that contains a variable count of carbonyl and primary and tertiary amine groups in their internal branching network along with multifunctional active or passive terminal groups.

Polyamidoamine (PAMAM), a starburst dendrimer, provides malleable molecular size, functionalized molecular structure and penetrable brain barrier characteristics. Therefore, PAMAM-based nanodrug delivery systems (PAMAM …

2014年3月13日 · Poly(amidoamine) (PAMAM) dendrimers are a novel class of spherical, well-designed branching polymers with interior cavities and abundant terminal groups on the surface which can form stable complexes with drugs, plasmid DNA, oligonucleotides, and antibodies.

2001年4月15日 · Poly (amidoamine) (PAMAM) dendrimers are the first complete dendrimer family to be synthesized, characterized and commercialized. Based on this extensive activity, they are recognized as a unique new class of synthetic nanostructures.

Directing groups to reach selective delivery in a specific organ is one of the advanced applications of PAMAM. In this review, structural and safety aspects of PAMAM and its derivatives are discussed, and some relevant applications are briefly presented.

Poly (amidoamine) (PAMAM) dendrimers are repetitively branched, three-dimensional molecules, made of amide and amine subunits, possessing unique physiochemical properties.