Osteoporosis: Pathophysiology and therapeutic options - PMC
The crucial role of remodeling in overall bone homeostasis is highlighted by the fact that impaired remodeling favoring bone resorption over bone formation is a fundamental pathophysiological …
Molecular and Cellular Mechanisms of Osteoporosis - PMC
Experimental and clinical studies devoted to investigating the main pathogenetic mechanisms of osteoporosis development revealed the important role of estrogen deficiency, inflammation, …
Molecular Mechanisms and Emerging Therapeutics for Osteoporosis
This review will discuss the etiology of osteoporosis and the molecular mechanism of bone modeling, current pharmacological options, emerging therapies targeting novel mechanisms, …
Osteoporosis - StatPearls - NCBI Bookshelf
2023年8月4日 · Osteoporosis is defined as low bone mineral density caused by altered bone microstructure, ultimately predisposing patients to low-impact, fragility fractures. Osteoporotic …
Osteoporosis - Osteoporosis - MSD Manual Professional Edition
The major mechanism of bone loss is increased bone resorption, resulting in decreased bone mass and microarchitectural deterioration, but sometimes bone formation is impaired. The …
Pathophysiology | International Osteoporosis Foundation
Osteoblasts, through a yet poorly characterized mechanism, lay down new bone mineral. The balance between the activities of these two cell types governs whether bone is made, …
A road map for understanding molecular and genetic ... - Nature
2019年12月2日 · In this Review, we highlight findings from genome-wide association studies and studies using various omics technologies individually to identify mechanisms of osteoporosis. …
Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics
2023年9月26日 · Understanding the cellular and molecular mechanisms underlying osteoporosis is essential for appropriate diagnosis and management of the condition.
Osteoporosis: Pathophysiology and therapeutic options
2020年7月20日 · Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic bone resorption not compensated by osteoblastic bone formation. This causes …
Osteoporosis: Mechanism, Molecular Target, and Current …
Osteoporosis is a pathological loss of bone mass due to an imbalance in bone remodeling where osteoclast-mediated bone resorption exceeds osteoblast-mediated bone formation resulting in …