Identification of osteoclast-osteoblast coupling factors in …
2020年1月7日 · Here we utilize osteoclast ablation by denosumab (DMAb) and RNA-sequencing of bone biopsies from postmenopausal women to identify osteoclast-secreted factors suppressed by DMAb. Based on...
Stepwise cell fate decision pathways during osteoclastogenesis at ...
2020年12月7日 · This study identified that CD11c is a molecule transiently expressed at an early stage of osteoclastogenesis and can be used as a marker for osteoclast precursor cells at specific stages,...
Unraveling the intricacies of osteoclast differentiation and …
2024年2月1日 · Osteoclasts are the principal cells that efficiently resorb bone. Numerous studies have attempted to reveal the molecular pathways leading to the differentiation and activation of osteoclasts to...
New Insights Into Osteoclast Biology - PMC - National Center for ...
2021年8月30日 · Several studies have shown that immature CD11c+ dendritic cells have the ability to differentiate into osteoclasts in vitro, resorb bone, and have an equivalent expression of main osteoclast markers as monocyte‐derived osteoclasts, especially during pathological (inflammatory) conditions.
Osteoclast - an overview | ScienceDirect Topics
Osteoclasts are rich in matrix-degrading enzymes, particularly cathespin K and matrix metalloproteinases (MMPs) and a tartrate-resistant acid phosphatase (TRAP) isoenzyme which provides a histochemical marker commonly used to identify osteoclast activity.
Beyond resorption: osteoclasts as drivers of bone formation
5 天之前 · Emerging evidence illustrates that osteoclasts (OCs) play diverse roles beyond bone resorption, contributing significantly to bone formation and regeneration. ... Kostakis P, Vincent C, Farrugia AN, Houchins JP, Findlay DM, et al. RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant ...
Osteoclast biology in the single-cell era - PMC - National Center …
2022年9月2日 · Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as well as bone damage under pathological conditions such as osteoporosis, arthritis, periodontitis, and bone metastasis.
Origin of Osteoclasts: Osteoclast Precursor Cells - PMC
2023年5月31日 · Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied.
Expression of typical osteoclast markers by PBMCs after PEG
Osteoclast involvement in this physiological event is regulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κB ligand (RANKL). Fusion of mono-nuclear pre-osteoclasts is a critical event for osteoclast differentiation and for bone resorption.
Osteoblast and Osteoclast Markers - R&D Systems
R&D Systems offers products that can be used as cell-type specific markers for osteoblasts (i.e. osteocalcin, DMP-1, osteoahderin) and osteoclasts (i.e. RANK, OSCAR, Calcitonin).