Orexins and appetite regulation - PubMed
Crucial evidence indicates that orexin-A increases food intake by delaying the onset of a behaviourally normal satiety sequence. In contrast, a selective orexin-1 receptor antagonist …
The role of orexin in motivated behaviours - Nature
2014年10月10日 · Orexins are lateral hypothalamic neuropeptides that have a highly important role in the regulation of wakefulness. To support feeding behaviour, orexin neurons are excited …
Role of orexin in modulating arousal, feeding, and motivation
Orexin deficiency results in narcolepsy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness. However, orexin neurons are …
Rethinking the Role of Orexin in the Regulation of REM Sleep and Appetite
2023年8月22日 · This review explores, first, the current evidence on the role of orexin in the modulation of sleep and wakefulness and highlights that orexin should be considered …
Orexins (hypocretins): their role in appetite and arousal
Destruction of lateral hypothalamic areas results in underfeeding, and orexins were thought to be the substances mediating appetite-stimulating drives. Further studies indicate a more complex …
Orexins and appetite regulation - ScienceDirect
2002年10月1日 · Since the orexin system is selectively activated by signals indicating severe nutritional depletion, it would be highly adaptive for a hungry animal not only to seek …
Ghrelin and orexin interact to increase meal size through a …
2020年6月1日 · Present data show that orexin input to the LDTg plays a role in food intake and satiation signaling, as ORX-1R blockade in the LTDg eliminated the effects of vHPC ghrelin to …
Motivational activation: a unifying hypothesis of orexin ... - Nature
2014年9月25日 · Notably, orexin neurons are active during hunger and help to translate peripheral hunger signals into increased appetitive responding for food and food cues …
Orexin-A controls sympathetic activity and eating behavior
2014年9月8日 · Orexin-A is a hypothalamic neuropeptide involved in the regulation of feeding behavior, sleep-wakefulness rhythm, and neuroendocrine homeostasis. This neuropeptide is …
Orexins and appetite regulation - ScienceDirect
2002年10月1日 · Crucial evidence indicates that orexin-A increases food intake by delaying the onset of a behaviourally normal satiety sequence. In contrast, a selective orexin-1 receptor …