Orexin - Wikipedia
There are 50,000–80,000 orexin-producing neurons in the human brain, [8] located predominantly in the perifornical area and lateral hypothalamus. [5][9] They project widely throughout the central nervous system, regulating wakefulness, feeding, and other behaviours. [5] .
The physiological role of orexin/hypocretin neurons in the …
A schematic diagram to illustrate the integrative physiological roles of orexin neurons. Orexin neurons regulate various physiological phenomena such as wakefulness, feeding, reward, and thermogenesis. The body energy level influences orexin neuronal activity to coordinate arousal and energy homeostasis.
Neurobiology of the Orexin System and Its Potential Role in the ...
Physiological studies have shown that orexin lengthens, and orexin disruption shortens continuous periods of wakefulness. Furthermore, loss of orexin neurons or receptors are hallmarks of narcolepsy/cataplexy in animals and humans.
Orexin System: The Key for a Healthy Life - PMC
Orexin neurons are “multi-tasking” neurons regulating a set of vital body functions, including sleep/wake states, feeding behavior, energy homeostasis, reward systems, cognition and mood. Furthermore, a dysfunction of orexinergic system may underlie different pathological conditions.
Orexin neurons inhibit sleep to promote arousal - Nature
2022年7月18日 · Here we show using in vivo optogenetics, in vitro optogenetic-based circuit mapping, and single-cell transcriptomics that orexin neurons also contribute to arousal maintenance through indirect...
Orexin System: The Key for a Healthy Life - Frontiers
2017年5月30日 · Orexin neurons are “multi-tasking” neurons regulating a set of vital body functions, including sleep/wake states, feeding behavior, energy homeostasis, reward systems, cognition and mood. Furthermore, a dysfunction of orexinergic system may underlie different pathological conditions.
Orexin - an overview | ScienceDirect Topics
Orexin is a neuropeptide produced in the hypothalamus that regulates the sleep-wake cycle and autonomic functions in the brain. It includes two types of orexin (orexin A and orexin B) and two types of orexin receptors (OX1R and OX2R) that are distributed in different regions of the brain.
Control of arousal by the orexin neurons - PMC - National Center …
2016年10月13日 · Orexin neurons innervate and excite monoaminergic brain regions such as the locus coeruleus, dorsal raphe, ventral tegmental area, and tubermomammillary nucleus. The orexin neurons also activate cortical neurons directly and indirectly via …
The role of orexin in motivated behaviours - Nature
2014年10月10日 · Orexins are lateral hypothalamic neuropeptides that have a highly important role in the regulation of wakefulness. To support feeding behaviour, orexin neurons are excited by food-related cues...
The neural circuit of orexin (hypocretin): maintaining sleep and ...
2007年2月14日 · Orexin neurons regulate monoaminergic and cholinergic nuclei in the brain stem to regulate sleep and wakefulness. Orexin neurons also have links with the arcuate nucleus that...